| Synonym |
| Thai / English name |
Part Used : ใบActivity : ANTIBACTERIAL ACTIVITYSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : TOB (1xMlC*) + TTO (0.05% v/v)Duration : 24 h. (Sample for viable counting were withdrawn at 0, 1, 2, 4, 8, 12 and 24 h.)Type of interaction : PharmacodynamicsInteraction with drug : Tobramycin*/Nebramycin 6Dose/Conc.(drug) : -Result : PositiveRemark : *Dose: The MlCs of TOB and TTO for E. coli = 0.39 mg/l and 0.25% v/v, respectively. Results: In the combination assays, the association of TOB (1xMlC) with TTO determined a reduction of >5 log10 for E. coli after 8h incubation time, whereas a faster reduction was observed incubating with TOB (2xMlC) and TTO (1/2xMlC).Note : TOB = tobramycin TTO = tea tree oil PAE = post antibiotic effect PASME = post antibiotic sub-MlC effect MlC = Minimum lnhibitory Concentrations The combination between TOB and TTO had a synergistic effect against the two stains investigated, the Gram-negative strain being overall more susceptible than the Gram-positive strain. TOB and TTO acted synergistically against both S. aureus and E. coli and this trend was confirmed by longer PAEs observed with the association. In order to investigate the increase in the post antibiotic effect of the association antibiotic/TTO, bacterial cells were further incubated with sub-MlC concentrations of TOB: an increase in the PAE and very long PASMEs were recorded when 0.50% (v/v) TTO was used.
Part Used : ใบActivity : ANTIBACTERIAL ACTIVITYSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : TOB (2xMlC*) + TTO (0.05% v/v)Duration : 24 h. (Sample for viable counting were withdrawn at 0, 1, 2, 4, 8, 12 and 24 h.)Type of interaction : PharmacodynamicsInteraction with drug : Tobramycin*/Nebramycin 6Dose/Conc.(drug) : -Result : PositiveRemark : *Dose: The MlCs of TOB and TTO for E. coli = 0.39 mg/l and 0.25% v/v, respectively. Results: In the combination assays, the association of TOB (1xMlC) with TTO determined a reduction of >5 log10 for E. coli after 8h incubation time, whereas a faster reduction was observed incubating with TOB (2xMlC) and TTO (1/2xMlC).Note : TOB = tobramycin TTO = tea tree oil PAE = post antibiotic effect PASME = post antibiotic sub-MlC effect MlC = Minimum lnhibitory Concentrations The combination between TOB and TTO had a synergistic effect against the two stains investigated, the Gram-negative strain being overall more susceptible than the Gram-positive strain. TOB and TTO acted synergistically against both S. aureus and E. coli and this trend was confirmed by longer PAEs observed with the association. In order to investigate the increase in the post antibiotic effect of the association antibiotic/TTO, bacterial cells were further incubated with sub-MlC concentrations of TOB: an increase in the PAE and very long PASMEs were recorded when 0.50% (v/v) TTO was used.
Part Used : ใบActivity : ANTIBACTERIAL ACTIVITYSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : TOB (2xMlC**) + TTO (0.05% v/v)Duration : 24 h. (Sample for viable counting were withdrawn at 0, 1, 2, 4, 8, 12 and 24 h.)Type of interaction : PharmacodynamicsInteraction with drug : Tobramycin*/Nebramycin 6Dose/Conc.(drug) : -Result : PositiveRemark : *Dose: The MlCs of TOB and TTO for S. aureus = 0.20 mg/l and 0.50% v/v, respectively. Results: In the association killing curve a synergistic effect was observed when treating S. aureus with tobramycin in combination with TTO, and a concentration-dependent killing was exerted. A reduction of >5log10 was shown after 4 and 8h with TOB (2XMlC) and TTO 0.50 (v/v) and 0.25% (v/v), respectively.Note : TOB = tobramycin TTO = tea tree oil PAE = post antibiotic effect PASME = post antibiotic sub-MlC effect MlC = Minimum lnhibitory Concentrations The combination between TOB and TTO had a synergistic effect against the two stains investigated, the Gram-negative strain being overall more susceptible than the Gram-positive strain. TOB and TTO acted synergistically against both S. aureus and E. coli and this trend was confirmed by longer PAEs observed with the association. In order to investigate the increase in the post antibiotic effect of the association antibiotic/TTO, bacterial cells were further incubated with sub-MlC concentrations of TOB: an increase in the PAE and very long PASMEs were recorded when 0.50% (v/v) TTO was used.
Part Used : ใบActivity : ANTIBACTERIAL ACTIVITYSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : TOB (2xMlC**) + TTO (0.25% v/v)Duration : 24 h. (Sample for viable counting were withdrawn at 0, 1, 2, 4, 8, 12 and 24 h.)Type of interaction : PharmacodynamicsInteraction with drug : Tobramycin*/Nebramycin 6Dose/Conc.(drug) : -Result : PositiveRemark : *Dose: The MlCs of TOB and TTO for S. aureus = 0.20 mg/l and 0.50% v/v, respectively. Results: In the association killing curve a synergistic effect was observed when treating S. aureus with tobramycin in combination with TTO, and a concentration-dependent killing was exerted. A reduction of >5log10 was shown after 4 and 8h with TOB (2XMlC) and TTO 0.50 (v/v) and 0.25% (v/v), respectively.Note : TOB = tobramycin TTO = tea tree oil PAE = post antibiotic effect PASME = post antibiotic sub-MlC effect MlC = Minimum lnhibitory Concentrations The combination between TOB and TTO had a synergistic effect against the two stains investigated, the Gram-negative strain being overall more susceptible than the Gram-positive strain. TOB and TTO acted synergistically against both S. aureus and E. coli and this trend was confirmed by longer PAEs observed with the association. In order to investigate the increase in the post antibiotic effect of the association antibiotic/TTO, bacterial cells were further incubated with sub-MlC concentrations of TOB: an increase in the PAE and very long PASMEs were recorded when 0.50% (v/v) TTO was used.
Part Used : ใบActivity : ANTIBACTERIAL ACTIVITYSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : TOB (0.1, 0.2, 0.3xMlC*) + TTO (0.05% v/v)Duration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Tobramycin*/Nebramycin 6Dose/Conc.(drug) : 0.1, 0.2, 0.3xMlC*Result : PositiveRemark : *Dose: The MlCs of TOB and TTO for E. coli = 0.39 mg/lNote : TOB = tobramycin TTO = tea tree oil PAE = post antibiotic effect PASME = post antibiotic sub-MlC effect MlC = Minimum lnhibitory Concentrations The combination between TOB and TTO had a synergistic effect against the two stains investigated, the Gram-negative strain being overall more susceptible than the Gram-positive strain. TOB and TTO acted synergistically against both S. aureus and E. coli and this trend was confirmed by longer PAEs observed with the association. In order to investigate the increase in the post antibiotic effect of the association antibiotic/TTO, bacterial cells were further incubated with sub-MlC concentrations of TOB: an increase in the PAE and very long PASMEs were recorded when 0.50% (v/v) TTO was used.
Part Used : ใบActivity : ANTIBACTERIAL ACTIVITYSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : TOB (0.1, 0.2, 0.3xMlC**) + TTO (0.05% v/v)Duration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Tobramycin*/Nebramycin 6Dose/Conc.(drug) : 0.1, 0.2, 0.3xMlC**Result : PositiveRemark : **Dose: The MlCs of TOB and TTO for S. aureusi = 0.20 mg/lNote : TOB = tobramycin TTO = tea tree oil PAE = post antibiotic effect PASME = post antibiotic sub-MlC effect MlC = Minimum lnhibitory Concentrations The combination between TOB and TTO had a synergistic effect against the two stains investigated, the Gram-negative strain being overall more susceptible than the Gram-positive strain. TOB and TTO acted synergistically against both S. aureus and E. coli and this trend was confirmed by longer PAEs observed with the association. In order to investigate the increase in the post antibiotic effect of the association antibiotic/TTO, bacterial cells were further incubated with sub-MlC concentrations of TOB: an increase in the PAE and very long PASMEs were recorded when 0.50% (v/v) TTO was used.
Part Used : ใบActivity : ANTIBACTERIAL ACTIVITYSolvent/Active Compound : Essential oilType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : TOB (0.1, 0.2, 0.3xMlC**) + TTO (0.25% v/v)Duration : 24 h.Type of interaction : PharmacodynamicsInteraction with drug : Tobramycin*/Nebramycin 6Dose/Conc.(drug) : 0.1, 0.2, 0.3xMlC**Result : PositiveRemark : **Dose: The MlCs of TOB and TTO for S. aureusi = 0.20 mg/lNote : TOB = tobramycin TTO = tea tree oil PAE = post antibiotic effect PASME = post antibiotic sub-MlC effect MlC = Minimum lnhibitory Concentrations The combination between TOB and TTO had a synergistic effect against the two stains investigated, the Gram-negative strain being overall more susceptible than the Gram-positive strain. TOB and TTO acted synergistically against both S. aureus and E. coli and this trend was confirmed by longer PAEs observed with the association. In order to investigate the increase in the post antibiotic effect of the association antibiotic/TTO, bacterial cells were further incubated with sub-MlC concentrations of TOB: an increase in the PAE and very long PASMEs were recorded when 0.50% (v/v) TTO was used.
