ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เหง้า

Activity : DRUG INTERACTION

Solvent/Active Compound : 1' S-1'-acetoxyeugenol acetate (AEA)

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 0-30 micromolar/L

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Paclitaxel*/Taxol/PTX

Dose/Conc.(drug) : 0-20 micromolar/L

Result : Positive

Remark : it was found the AEA was able to reduce the viability levels of MCF-7 cells to a higher extent when used in combination with paclitaxel. Cl analysis indicated that synergistic effects were observed for all combinations of paclitaxel and AEA for 24 h (Cl=0.51-0.66). However, a shift toward an antagonistic effect was observed when treatment of MCF-7 cells was allowed to proceed for 48 h, indicated that this sensitization effect was found to have a transient effect, diminishing upon 48 h of incubation.

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