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| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : humanType of animal : -Type of study : -N(Total) : 1N(Treatment) : 1Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Possible interaction with warfarin in 1 case.Note : Data incomplete, data from review article.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Possible interaction with warfarin in 1 case; pro-thrombin time lowered with concurrent administration in rabbits. Avoid with cancer chemotherapy.Note : Data from review, data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Possible interaction with warfarin in 1 case; pro-thrombin time lowered with concurrent administration in rabbits. Avoid with cancer chemotherapy.Note : Data from review, data incomplete.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : 3 daysType of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : The effects of root of Angelica sinensis (RAS) on the pharmacokinetics and pharmacodynamics of warfarin in rabbits showed RAS treatment did not affect prothrombin time (PT) by itself, but significantly lowered PT values three days after co-treatment with single dose warfarin. The results indicate that precautionasy advice should be given to patients who self-medicate with RAS while on chronic treatment with warfarin.Note : Data from reviews article.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : FemaleAge : -Route : Oral administrationDose/Conc.(herb) : once or twice daily (not specified dose)Duration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : 5 mg/dResult : PositiveRemark : A woman who had been taking warfarin 5 mg/d for nearly two years and had an international normalized ratio (lNR) stabilized at 2-3, experienced a sudden increase in hear lNR to 4.9. The patient said she recent addition of root of Angelica sinensis (RAS) once or twice daily during the preceding four weeks for the management of menopausal symptoms. The patient was instructed to discontinue RAS, and her lNR declined to the therapeutic range within four weeks.Note : Data from reviews article.
