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Part Used : ไม่ระบุActivity : ARYL HYDROCARBON RECEPTOR ACTIVATIONSolvent/Active Compound : ginkgolide AType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : ginkgolide A 1.1 mcg/mLDuration : MCF-10A cells were treated with ginkgolide A for 24 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: None of the terpene trilactones increased CYP1B1 or CYP1A1 mRNA expression. These compounds also and had no effect on AhR dependent report activity.Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).
Part Used : ไม่ระบุActivity : ARYL HYDROCARBON RECEPTOR ACTIVATIONSolvent/Active Compound : ginkgolide BType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : ginkgolide B 0.3 mcg/mLDuration : MCF-10A cells were treated with ginkgolide B for 24 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: None of the terpene trilactones increased CYP1B1 or CYP1A1 mRNA expression. These compounds also and had no effect on AhR dependent report activity.Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).
Part Used : ไม่ระบุActivity : ARYL HYDROCARBON RECEPTOR ACTIVATIONSolvent/Active Compound : ginkgolide CType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : ginkgolide C 1.4 mcg/mLDuration : MCF-10A cells were treated with ginkgolide C for 24 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: None of the terpene trilactones increased CYP1B1 or CYP1A1 mRNA expression. These compounds also and had no effect on AhR dependent report activity.Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).
Part Used : ไม่ระบุActivity : ARYL HYDROCARBON RECEPTOR ACTIVATIONSolvent/Active Compound : ginkgolide JType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : ginkgolide J 0.6 mcg/mLDuration : MCF-10A cells were treated with ginkgolide J for 24 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: None of the terpene trilactones increased CYP1B1 or CYP1A1 mRNA expression. These compounds also and had no effect on AhR dependent report activity.Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).
Part Used : ไม่ระบุActivity : ARYL HYDROCARBON RECEPTOR ACTIVATIONSolvent/Active Compound : bilobalide, ginkgolide A, ginkgolide B, ginkgolide C, and ginkgolide JType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : bilobalide 2.8 mcg/mL, ginkgolide A 1.1 mcg/mL, ginkgolide B 0.3 mcg/mL, ginkgolide C 1.4 mcg/mL, and ginkgolide J 0.6 mcg/mLDuration : MCF-10A cells were treated with bilobalide, ginkgolide A, ginkgolide B, ginkgolide C, and ginkgolide J for 24 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: Additional analysis indicated that treatment of cells with the combination of bilobalide, ginkgolide A, ginkgolide B, ginkgolide C, and ginkgolide J also did not affect ArR-dependent reporter activity.Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).
Part Used : ไม่ระบุActivity : ARYL HYDROCARBON RECEPTOR ACTIVATIONSolvent/Active Compound : QuercetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : quercetin 10.6 mcg/mLDuration : MCF-10A cells were treated with quercetin for 48 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Quercetin increased AhR-dependent reporter activity by 8-fold, whereas kaempferol and isorhamnetin had no effect.Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).
Part Used : ไม่ระบุActivity : ARYL HYDROCARBON RECEPTOR ACTIVATIONSolvent/Active Compound : kaempferolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : kaempferol 6.3 mcg/mLDuration : MCF-10A cells were treated with kaempferol for 48 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: Quercetin increased AhR-dependent reporter activity by 8-fold, whereas kaempferol and isorhamnetin had no effect.Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).
Part Used : ไม่ระบุActivity : ARYL HYDROCARBON RECEPTOR ACTIVATIONSolvent/Active Compound : isorhamnetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : isorhamnetin 4.1 mcg/mLDuration : MCF-10A cells were treated with isorhamnetin for 48 hType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: Quercetin increased AhR-dependent reporter activity by 8-fold, whereas kaempferol and isorhamnetin had no effect.Note : Solvent/compound: Ginkgo biloba extract contained 6.2% w/w terpene trilactones, consisting of bilobalide (2.8%), ginkgolide A (1.1%), ginkgolide B (0.3%), ginkgolide C (1.4%), and ginkgolide J (0.6%). It also contained 21% w/w flavonols (as sum of the aglycone and glycosides), consisting of quercetin (10.6%), kaempferol (6.3%), and isorhamnetin (4.1%).
