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GINKGOACEAE Ginkgo biloba L.

Synonym

none ...

Thai / English name

แปะก๊วย*

[27-32] of 51 article(s) found

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[27] EFFECTS OF A 4-WEEK DIET OF GINKGO BILOBA EXTRACT ON THE CARDIOVASCULAR FUNCTION OF AGED RATS.
KUBOTA Y,KOBAYASHI K,TANAKA N,ET AL.
NIPPON SHOKUHIN KAGAKU GAKKAISHI 2004 Vol.11(2),81-5 287209 [Abstract]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginkgo biloba extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : 4 weeks
Type of interaction : Pharmacokinetics

Interaction with drug : Nicardipine
Dose/Conc.(drug) : -

Result : Positive

Remark : The hypotensive effect of nicardipine was significantly reduced in the rats fed ginkgo biloba extract for 4 wk.

Note : Data incomplete

[28] GLUCURONIDATION AND IN VITRO INTERACTION OF GINGKO FLAVONOIDS WITH OTHER DRUGS.
ZHU M,YAO T,ZENG S
ZHEJIANG DAXUE XUEBAO, YIXUEBAN 2004 Vol.33(1),15-20 287762 [Abstract]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginkgo flavonoids

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Nifedipine
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: rat hepatic microsome Results: Nifedipine, propafenone and ipriflavone inhibit the metabolism of Ginkgo flavonoids (quercetin, isorhamnetin and kaempferol) at different levels.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginkgo flavonoids

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Propafenone
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: rat hepatic microsome Results: Nifedipine, propafenone and ipriflavone inhibit the metabolism of Ginkgo flavonoids (quercetin, isorhamnetin and kaempferol) at different levels.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginkgo flavonoids

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Ipriflavone
Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment: rat hepatic microsome Results: Nifedipine, propafenone and ipriflavone inhibit the metabolism of Ginkgo flavonoids (quercetin, isorhamnetin and kaempferol) at different levels.

Note : Data incomplete

[29] THE EFFECT OF MECLOFENOXATE WITH GINKGO BILOBA EXTRACT OR ZINC ON LIPID PEROXIDE, SOME FREE RADICAL SCAVENGERS AND THE CARDIOVASCULAR SYSTEM OF AGED RATS.
AL-ZUHAIR H,EL-FATTAH AAA,EL-SAYED MI
PHARMACOL RES 1998 Vol.38(1),65-72 293265 [Abstract]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : extract of ginkgo biloba (EGb-761)

Type of experiment : -
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 150 mg/kg

Duration : 4 weeks
Type of interaction : P.Kinetics & P.Dynamics

Interaction with drug : Meclofenoxate*/Clophenoxate/Meclophenoxate/Centrophenoxine
Dose/Conc.(drug) : 100 mg/kg daily

Result : Positive

Remark : Type of experiment: Aged rats were treated with meclofenoxate (MF) alone or with either EGb or Zn for 4 wk. Results: Treatment of aged rats with MF alone or combined with either EGb or Zn caused improvement in the measured free radical scavengers esp. in brain and heart. Both EGb and Zn induced a potential effect of MF action on blood pressure and heart rate.

Note : Data incomplete

[30] GINKGO BILOBA DOES NOT ALTER CLEARANCE OF FLURBIPROFEN, A CYTOCHROME P450-2C9 SUBSTRATE.
GREENBLATT DJ,VON MOLTKE LL,LUO Y,ET AL.
J CLIN PHARMACOL 2006 Vol.46(2),214-21 318171 [Abstract]

Part Used : ใบ
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Double-blind trial

N(Total) : 11
N(Treatment) : 11

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : *

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Flurbiprofen
Dose/Conc.(drug) : -

Result : Positive

Remark : Dose: * Single 100 mg dose of flurbiprofen + standardized G. biloba leaf preposition (Ginkgold, 3 doses of 120 mg) - Each 60 mg Ginkgold tablet contained 6.6 microgram of amentoflavone and 61.2 microgram of quercetin. - Mean kinetic variables for flurbiprofen with either placebo or G. biloba were elimination half-life, 3.9 vs. 3.5 h; total AUC, 57 vs. 55 microgram/mL per hour; and oral clearance 32.9 vs. 31.6 mL/min. None of these differences was significant.

Note : - Data incomplete

Part Used : ใบ
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Cross over

N(Total) : 11
N(Treatment) : 11

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : *

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Flurbiprofen
Dose/Conc.(drug) : -

Result : Positive

Remark : Dose: * Single 100 mg dose of flurbiprofen + standardized G. biloba leaf preposition (Ginkgold, 3 doses of 120 mg) - Each 60 mg Ginkgold tablet contained 6.6 microgram of amentoflavone and 61.2 microgram of quercetin. - Mean kinetic variables for flurbiprofen with either placebo or G. biloba were elimination half-life, 3.9 vs. 3.5 h; total AUC, 57 vs. 55 microgram/mL per hour; and oral clearance 32.9 vs. 31.6 mL/min. None of these differences was significant.

Note : - Data incomplete

[31] INDUCTION OF PROPRANOLOL METABOLISM BY GINKGO BILOBA EXTRACT EGB 761 IN RATS.
ZHAO L-Z,HUANG M,CHEN J,ET AL.
CURR DRUG METAB 2006 Vol.7(6),577-87 318757 [Abstract]

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : EGB761 10 mg/kg/day

Duration : 10 days
Type of interaction : Pharmacokinetics

Interaction with drug : Propranolol*/Propanolol/Beta-propranolol
Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11. - Data incomplete

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : EGB761 100 mg/kg/day

Duration : 10 days
Type of interaction : Pharmacokinetics

Interaction with drug : Propranolol*/Propanolol/Beta-propranolol
Dose/Conc.(drug) : -

Result : Positive

Remark : Pretreatment of EGB761 at 100 mg/kg for 10 days significantly reduced the area uder the plasma concentration time curve (AUC) and maximum plasma concentration (Cmax) of propranolol, whereas those values of N-desisopropylpropranolol (NDP) were significantly increased.

Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11. - Data incomplete

[32] MARKED DECREASE OF CYCLOSPORIN BIOAVAILABILITY CAUSED BY COADMINISTRATION OF GINKGO AND ONION IN RATS.
YANG CY,CHAO PDL,HOU YC,ET AL.
FOOD CHEM TOXICOL 2006 Vol.44(9),1572-8 324197 [Abstract]

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyA
Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : - Cyclosporin was administered orally and i.v. to rats with and without an oral dose of ginkgo or onion in crossover designs. - Oral coadministration of ginkgo and onion significantly decreased the Cmax of cyclosporine by 62% and 60%, and reduced the AUC0-t by 51% and 68%, respectively, whereas no influence observed when cyclosporine was given by i.v. - Data incomplete.

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