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| Thai / English name |
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 35N(Treatment) : 18Sex : -Age : childrenRoute : Non-specifiedDose/Conc.(herb) : -Duration : 8 weeksType of interaction : PharmacodynamicsInteraction with drug : Prednisone*/Deltacortisone/DeltdehydrocortisoneDose/Conc.(drug) : -Result : PositiveRemark :Note : - Thirty-five children with nephritic syndrome were divided into 2 groups, randomly. The treatment group (n = 18), treated with prednisone plus extract of ginkgo biloba leaf. The control group (n = 17), treated with prednisone plus dipyridamole. - After 8 wk treatment, the clinical symptom and biochemistry assay were ameliorated in Ginkgo biloba group than that in the dipyridamole group (P<0.01). The levels of 24-h urine protein and the hypercoagulability marker were also ameliorated.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : -Type of interaction : PharmacodynamicsInteraction with drug : DoxycyclineDose/Conc.(drug) : -Result : PositiveRemark : The obtained results showed significant protection by G. biloba ext. against doxycyclin-induced phototoxicity.Note : - Doxycycline (400 mg/kg) was administered orally. Two dose levels of G. biloba ext. were utilized (100 and 200 mg/kg p.o.). Mice were exposed to UV-A radiation one hour after administration of doxycyclin. UV-A radiation was directed to the animal's ears for 210 min. at a dose of 25 Jol/cm2. Immediately after irradiation, animals were given a single dose of G. biloba ext. - Data incomplete.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 200 mg/kgDuration : -Type of interaction : PharmacodynamicsInteraction with drug : DoxycyclineDose/Conc.(drug) : -Result : PositiveRemark : The obtained results showed significant protection by G. biloba ext. against doxycyclin-induced phototoxicity.Note : - Doxycycline (400 mg/kg) was administered orally. Two dose levels of G. biloba ext. were utilized (100 and 200 mg/kg p.o.). Mice were exposed to UV-A radiation one hour after administration of doxycyclin. UV-A radiation was directed to the animal's ears for 210 min. at a dose of 25 Jol/cm2. Immediately after irradiation, animals were given a single dose of G. biloba ext. - Data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 233N(Treatment) : -Sex : FemaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : The study identified use of 35 different typed of complimentary alternative medicine products and seven of these could potentially increase the risk of breast cancer or interact with tamoxifen or aromatase inhibitiors: soy, garlic, Ginkgo biloba, Echinacea, ginseng, velerian and phytoestrogens (excluding soy).Note : Data incomplete Subject were consecutive breast cancer patients
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Gingko biliba extract (GBE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Diet containing 0.5% GBEDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : Phenylephrine*/L-Phenylephrine/MetasympatolDose/Conc.(drug) : -Result : NegativeRemark : GBE feeding did not affect contractile response to phenylephrine, relaxation responses to not only sodium nitroprusside but also acetylcholine, and protein levels of endothelium nitric oxide synthase and sol. guanylate cyclase in aortas of aged spontaneously hypertensive rats.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Ginkoba tabletType of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : MaleAge : 70 yearsRoute : Oral administrationDose/Conc.(herb) : Ginkoba tablet twice daily, each tablet contained 40 mg of concentrated (50:1) extract of G. biloba tree.Duration : 1 weeksType of interaction : P.Kinetics & P.DynamicsInteraction with drug : Aspirin*/Acetylsalicylic acid/ASA/EcosprinDose/Conc.(drug) : 325 mg tablet/dayResult : -Remark : A 70-year-old man presented after two days of recurrent blurred vision in the right eye, with each episode lasting 15 minutes, during which he could perceive a red discoloration through his cornea. The patient stopped taking the ginkgo extract but continued to take daily aspirin, and there was no recurrence of bleeding over a three month follow-up period.Note : Data incomplete
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Ginkgo biloba extract (GBE)Type of experiment : humanType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : PositiveRemark : The pupose of study was to assess the ability of single midazolam concentrations to predict midazolam AUC in the presence and absence of CYP3A modulation by GBE. Subjects received oral midazolam 8 mg before and after 28 days of GBE administration. The geometric mean raio (90% confidence intervals) of midazolam AUC 0-infinity - GBE / AUC 0-infinity pre - GBE was 0.66 (0.49-0.84) P = .03). Single midazolam concentrations between 2 and 5 hours correctly predicted the reduction in midazolam AUC following GBE exposure, but confidence intervals were generally wide.Note : Data incomplete.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : Extract of Ginkgo biloba (Egb761)Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 60*N(Treatment) : -Sex : FemaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Doxorubicin*/Adrimycin/ADR/AdriaDose/Conc.(drug) : -Result : PositiveRemark :Note : *Sixty breast cancer patients in stage IV were randomly assigned to two groups, the control group was treated with chemotherepy, using 4 cycles of PA protocol alone and the treated group with the same chemotherapy and Egb761. Egb761 prevented and reduced the acute doxorubicin-induced cardiotoxicity and could helpful for alleviating the chronic cardiotoxicity. - Data incomplete.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : Ginkgo-DipyridamolumType of experiment : humanType of animal : -Type of study : Case-controlN(Total) : 40N(Treatment) : 20Sex : -Age : -Route : IntravenousDose/Conc.(herb) : 20 mL Ginkgo-Dipyridamolum injection + 100 mL normal salineDuration : 4 weeksType of interaction : PharmacodynamicsInteraction with drug : ValsartanDose/Conc.(drug) : -Result : PositiveRemark :Note : - 40 patients with early diabetic nephropathy divided into A and B group. A group was given oral 80 mg valsartan, once a day, 20 mL Ginkgo-Dipyridamolum injection + 100 mL normal saline by i.v. injection once a day. B group was given 80 mg/d vasartan lasted for 4 weeks. - After therapy, the decrease of urinary albumin, total cholesterol, total triglyceride, whole blood viscosity, plasma viscosity, fibrinogen, hematocrit was more evident in A group than in B group, and the difference had significance (P<0.05,P<0.01). - Data incomplete.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 14*N(Treatment) : 7**Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : Voriconazole 200 mg after administration of Ginkgo biloba 120 mg twice daily.Duration : 12 daysType of interaction : PharmacokineticsInteraction with drug : VoriconazoleDose/Conc.(drug) : -Result : EquivocalRemark : * Healthy and nonsmoking volunteers. ** CYP2C19 extensive metabolizers (2C19*1/2C19*1). Results: For extensive metabolizers, the median value for voriconazole area under the plasma concentration time cruve from zero to infinity (AUC0-infinity) was 5.17 microgram/mL after administration of voriconazole alone and 4.28 microgram/mL after voriconazole with Ginkgo biloba (p>0.05). The other pharmacokinetic parameters of voriconazole such as AUC0-24, time to reach maximum concentration, half-life, and apparent clearance also did not change significantly for expensive metabolizers in the presence of Ginkgo biloba.Note : - 2 phase randomized crossover study with 4 weeks washout between phases. - Data incomplete.
