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GINKGOACEAE Ginkgo biloba L.

Synonym

none ...

Thai / English name

แปะก๊วย*

[3-7] of 7 article(s) found

หน้า 1 2

[3] INHIBITORY EFFECTS OF POLYPHENOLS ON HUMAN CYTOCHROME P450 3A4 AND 2C9 ACTIVITY.
KIMURA Y,ITO H,OHNISHI R,ET AL.
FOOD CHEM TOXICOL 2010 Vol.48(),429-35 $27410 [Full]

Part Used : -
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : Myricetin

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : Three coumarins and 12 flavonoids significantly suppressed CYP3A4 or CYP2C9 activities. Lineweaver-Burk plot analysis indicated that apigenin and its dimer amentoflavone and imperatorin displayed a mixed type of inhibition on CYP3A4 or CYP2C9. Among the inhibitors, amentoflavone was the most potent inhibitor of CYP3A4 and CYP2C9 activities with IC50 values of 0.07 and 0.03 micromolar, respectively. The Ki value of amentoflavone was significantly lower than that of the CYP2C9 inhibition positive control sulfaphenazole.

[4] THE EFFECT OF COMPLEMENTARY AND ALTERNATIVE MEDICINES ON CYP3A4-MEDIATED METABOLISM OF THREE DIFFERENT SUBSTRATES: 7-BENZYLOXY-4-TRIFLUOROMETHYL-COUMARIN, MIDAZOLAM AND DOCETAXEL.
MOOIMAN,KIM D.;MAAS-BAKKER,ROEL F.;HENDRIKX,JEROEN J.M.A.;ET AL.
J PHARM PHARMACOL 2014 Vol.66(6),865-74 $52931 [Full]

Part Used : ใบ
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : other

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 25 microgram/ml

Duration : 5 minutes
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Positive

Remark : - Details of the standardized Ginkgo extracts: 4.78% Quercetin, 3.73% Kaempferol, 2.13% Isorhamnetin, 12.0% Quercetin glycoside, 9.65% Kaempferol glycoside, 5.19% Isorhamnetin glycoside, 1.61% Bilobalide, 1.41% Ginkgolide A, 0.31% Ginkgolide J, 5.57% Ginkgolide B, 0.38% Ginkgolide C. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 45.9% and IC50 values of that inhibit CYP3A4-mediated metabolism of midazolam = 75.1 microgram/ml, 95% Cl: 53.0-106.

Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).

Part Used : ใบ
Activity : CYP3A4 INHIBITION

Solvent/Active Compound :

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 100 microgram/ml

Duration : 30 minutes
Type of interaction : Pharmacokinetics

Interaction with drug : Docetaxel*/Taxotere
Dose/Conc.(drug) : -

Result : Positive

Remark : - Details of the standardized Ginkgo extracts: 4.78% Quercetin, 3.73% Kaempferol, 2.13% Isorhamnetin, 12.0% Quercetin glycoside, 9.65% Kaempferol glycoside, 5.19% Isorhamnetin glycoside, 1.61% Bilobalide, 1.41 Ginkgolide A, 0.31% Ginkgolide J, 5.57% Ginkgolide B, 0.38% Ginkgolide C. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 45.1% and IC50 values of that inhibit CYP3A4-mediated metabolism of docetaxel = 155 microgram/ml, 95% Cl: 81.3-297.

Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).

[5] EVALUATIONOF IN VITRO INHIBITION AND INDUCTION OF CYTOCHROME P450 ACTIVITIES BY HYDROLYZED GINKGOLIDES.
XIAO-WEN ZHOU,ZHENG MA,TING GENG,ET AL.
J ETHNOPHARMACOL 2014 Vol.158(),132-9 $54363 [Full]

Part Used : ไม่ระบุ
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : ginkgolides

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.1 - 10 micrograms/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Within 0.1 to 10 micrograms/mL, the hydrolyzed ginkgolides showed direct inhibition against CYP1A2, 2B6,2C8,2C9,2C19,2D6,2E1,3A4m (midazolam as substrate) and 3A4t (testosterone as sustrate), with IC50 values determined to be 410 micrograms/mL (concentrations expressed as the sum of equivalent concentrations of ginkgolideA, B and K). For the metabolism-dependent inhibition studies, the preincubation of 30 min did not substantially alter the IC50 values when compared with the corresponding values in the direct inhibition studies. The activities and mRNA expression levels for CYP1A2 and 2B6 with in each drug-treated group (0.1, 1 and 10 micrograms/mL) were not affected after the 48-h incubation. For CYP3A4, the activity and mRNA expression level were not altered when incubated with 0.1 and 1 micrograms/mL of hydrolyzed ginkgolides. When incubated with hydrolyzed ginkgolides at 10 micrograms/mL, the relative activity and relative mRNA expression level of CYP3A4 remarkably increased to 4.59+/-3.67 and 17.2+/-9.16-fold of corresponding vehicle control values, respectively. The hydrolyzed ginkbolides is not likely to cause DDI via inhibition of the major human CYPs.

Note : DDI = drug-drug interaction

[6] INHIBITION OF HUMAN P450 ENZYMES BY MULTIPLE CONSTITUENTS OF THE GINKGO BILOBA EXTRACT.
GAUDINEAU C,BECKERMAN R,WELBOURN S,ET AL.
BIOCHEM BIOPHYS RES COMMUN 2004 Vol.318(4),1072-8 265522 [Abstract]

Part Used : ไม่ระบุ
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : Ginkgo biloba ext. (EGb761)

Type of experiment : non specified
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : The full ext. was found to a lesser inhibit CYP3A4 (Ki=155+/-43 microgram/mL.)

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : The terpenoidic fraction

Type of experiment : non specified
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : The terpenoidic fraction inhibited only CYP2C9 (Ki=15+/-6 microgram/mL.)

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : Flavonoidic fraction of EGb761

Type of experiment : non specified
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : The flavonoidic fraction of EGB761 showed high inhibition of CYP2C9, CYP1A2, CYP2E1, and CYP3A4 (ki's between 4.9 and 55 microgram/mL)

Note : Data incomplete

[7] EFFECTS OF GINKGO BILOBA EXTRACT ON PHARMACOKINETICS AND PHARMACODYNAMICS OF TOLBUTAMIDE AND MIDAZOLAM IN HEALTHY VOLUNTEERS.
UCHIDA S,YAMADA H,LI XD,ET AL.
J CLIN PHARMACOL 2006 Vol.46(11),1290-8 338393 [Abstract]

Part Used : ใบ
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : Ginkgo biloba extraction (GBE)

Type of experiment : human
Type of animal : -

Type of study : Open trial

N(Total) : 10
N(Treatment) : 10

Sex : Male
Age : -

Route : Oral administration
Dose/Conc.(herb) : GBE intake 360 mg/d

Duration : 28 days
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Positive

Remark : - Midazolam 8 mg were orally administered to 10 male healthy volunteers before and after GBE intake. - AUC0-alpha for midazolam was singnificantly (25%) increased by GBE intake and oral clearance was significantly (26%) decreased.

Note : - Data incomplete

หน้า 1 2

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