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Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : Flavonoidic fraction of EGb761Type of experiment : non specifiedType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : The flavonoidic fraction of EGB761 showed high inhibition of CYP2C9, CYP1A2, CYP2E1, and CYP3A4 (ki's between 4.9 and 55 microgram/mL)Note : Data incomplete
Part Used : ไม่ระบุActivity : CYP1A2 INHIBITIONSolvent/Active Compound : -Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Type of experiment: human liver microsomes Results: Weak or negligible inhibitory activity was found for the terpene trilactones (ginkgolides A, B, C and J, and bilobalide), and the flavonol glycosides. However 50% inhibitory activity (IC50) was found at concns. less than 10 microgram/ml for the flavonol aglycons (kaempferol, quercetin, apigenin, myricetin, tamarixetin) with CYP1A2 and CYP3A. Quercetin, the biflavone amentoflavone, sesamin, as well as (Z,Z)-4,4'-(1,4-pentadiene-1,5-diyl) diphenol and 3-nonadec-8-enylbenzene-1,2-diol, were also inhibitors of CYP2C9.Note : Data incomplete
