| Synonym |
| Thai / English name |
Part Used : ใบActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 11N(Treatment) : 11Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : *Duration : -Type of interaction : PharmacokineticsInteraction with drug : FlurbiprofenDose/Conc.(drug) : -Result : EquivocalRemark : Dose: * Single 100 mg dose of flurbiprofen + standardized G. biloba leaf preposition (Ginkgold, 3 doses of 120 mg) - Each 60 mg Ginkgold tablet contained 6.6 microgram of amentoflavone and 61.2 microgram of quercetin. - Mean kinetic variables for flurbiprofen with either placebo or G. biloba were elimination half-life, 3.9 vs. 3.5 h; total AUC, 57 vs. 55 microgram/mL per hour; and oral clearance 32.9 vs. 31.6 mL/min. None of these differences was significant.Note : - Data incomplete
Part Used : ไม่ระบุActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : Ginkgo extractType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Ginkgo extract 10 mMDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Many of the exts./constituents exerted >/=50% inhibition of P 450 activity. Ginkgo inhibiting CYP2C8 at 10mM.Note : Result: The data suggest that the clearance of a variety of drugs may be diminished by concomitant use of these herbs via inhibition of P450 enzymes, but less so by Pgp-mediated effects. Data incomplete.
Part Used : ใบActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : ginkgo biloba ext. (GBE)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Cells (E47 cells) of Ginkgo biloba ext. (GBE) and alc. group were cultured by 150 g/L GBE for 3 h, and then by alc. for 24 h.Duration : 3 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Compared with those of the alc. and fish oil groups, the expression and activity of CYP2E1 in E47 cells of fish oil and GBE group as well as alc. and GBE group were lower. GBE can inhibit the expression and activity of CYP2E1.Note : The expression of cytochrome P 450 2E1 (CYP2E1) protein in E47 cells was detected using Western blot, the CYP2E1 activity was measured using p-nitrophenol (PNP) probe. Cell cultured by Dulbecco's Modified Eagle's Medium (DMEM) were the controls. Data incomplete.
Part Used : ใบActivity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : ginkgo biloba ext. (GBE)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Cells of fish oil and GBE group were cultured by 150 g/L GBE for 3h, and then by fish oil for 24 h.Duration : 3 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: Compared with those of the alc. and fish oil groups, the expression and activity of CYP2E1 in E47 cells of fish oil and GBE group as well as alc. and GBE group were lower. GBE can inhibit the expression and activity of CYP2E1.Note : The expression of cytochrome P 450 2E1 (CYP2E1) protein in E47 cells was detected using Western blot, the CYP2E1 activity was measured using p-nitrophenol (PNP) probe. Cell cultured by Dulbecco's Modified Eagle's Medium (DMEM) were the controls. Data incomplete.
