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Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : tamarixetin (Tam)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Tam 10 mcg/mlDuration : Human primary hepatocytes (HL-#10 and HL-#13) in 24-well Biacoat plates were transfected with CYP2B6 reporter vactor (CYP2B6-2.2 kb) then treated with Tam for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: EGb 761, GA and GB were associated with enhanced expression of CYP2B6-2.2 kb reporter gene, presumably through the endogenous pregnane X receptor (PXR) and constitutive androstane receptor (CAR), whereas no activation was observed after the treatment with Que, Kae, and Tam. These results are consistent with the actual induction profiles of terpenoids and flavonoids in human primary hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ไม่ระบุActivity : CYP2B6 INDUCTIONSolvent/Active Compound : Ginkgo biloba extract*Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Gingko biloba extract did not alter hCAR or hPXR mRNA expression. Whereas the extract (100 mg/ml) increased CYP2B6 mRNA and CYP2B6-mediated bupropion hydroxylation, the increase was not attenuated by the co-treatment with a hGR antagonist. The same pattern of response was also obtained for CYP3A4 mRNA and CYP3A-mediated testosterone 6b-hydroxylation. Therefore, Ginkgo biloba extract induces CYP2B6 (a hCAR target gene) and CYP3A4 (a hPXR target gene) by a hGR-independent mechanism.Note : *Solvent/active compound: Ginkgo extract (Lot A) 200 micrgram/mL consist ginkogolide A, B, C, J and bilobalide as 2.2, 0.6, 2.8, 1.2 and 5.6 microgram/mL, respectively.
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : Ginkgo biloba leaf ext. (GBE)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Orphenadrine hydrochloride*/OrphenadrineDose/Conc.(drug) : -Result : NegativeRemark : The metabolism pathways involved for GBE were identified by preincubation of cryopreserved human primary hepatocytes (HPHs) with selective inhibitors of CYP2B6 (orphenadrine hydrochlorid).Note : Result: GBE showed the inhibition of PAF-induced platelet aggregation with IC50 of 33 mg/L-1, 30% enhancement over the control. These effects of GBE were reduced significantly by selectively inhibiting CYP1A2 but CYP2B6, 2C19, 2E1 and 3A4. The inhibitive effects of GBE on PAF induced platelet aggregation are regulated by CYP1A2. Data incomplete.
