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| Thai / English name |
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : bilobalide (BB)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : BB 50 microMDuration : Transfected cells were then treated with BB for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : EquivocalRemark : Result: Only marginal activation of human pregnane X receptor (hPXR) was observed after the treatment of BB, which was in agreement with the negligible induction of CYP2B6 and CYP3A4 by BB in human hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : quercetin (Que)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Que 25 mcg/mlDuration : Cultured human primary hepatocytes were treated for 24 h with QueType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: All flavonoids of EGb 761 failed to induce any tested human drug-metabolizing enzymes (DMEs) or drug transporters in human hepatocytes, revealing a discrepancy between the potent activation of NRs in HepG2 cells and the lack of induction of their target genes in human hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : kaempferol (Kae)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Kae 20 mcg/mlDuration : Cultured human primary hepatocytes were treated for 24 h with KaeType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: All flavonoids of EGb 761 failed to induce any tested human drug-metabolizing enzymes (DMEs) or drug transporters in human hepatocytes, revealing a discrepancy between the potent activation of NRs in HepG2 cells and the lack of induction of their target genes in human hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : tamarixetin (Tam)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Tam 10 mcg/mlDuration : Cultured human primary hepatocytes were treated for 24 h with TamType of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: All flavonoids of EGb 761 failed to induce any tested human drug-metabolizing enzymes (DMEs) or drug transporters in human hepatocytes, revealing a discrepancy between the potent activation of NRs in HepG2 cells and the lack of induction of their target genes in human hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : The standardized Ginkgo biloba leaf extract (EGb 761)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : EGb 761 100 mcg/mlDuration : Human primary hepatocytes (HL-#10 and HL-#13) in 24-well Biacoat plates were transfected with CYP2B6 reporter vactor (CYP2B6-2.2 kb) then treated with EGb 761 for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: EGb 761, GA and GB were associated with enhanced expression of CYP2B6-2.2 kb reporter gene, presumably through the endogenous pregnane X receptor (PXR) and constitutive androstane receptor (CAR), whereas no activation was observed after the treatment with Que, Kae, and Tam. These results are consistent with the actual induction profiles of terpenoids and flavonoids in human primary hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : qinkgolide A (GA)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : GA 50 microMDuration : Human primary hepatocytes (HL-#10 and HL-#13) in 24-well Biacoat plates were transfected with CYP2B6 reporter vactor (CYP2B6-2.2 kb) then treated with GA 761 for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: EGb 761, GA and GB were associated with enhanced expression of CYP2B6-2.2 kb reporter gene, presumably through the endogenous pregnane X receptor (PXR) and constitutive androstane receptor (CAR), whereas no activation was observed after the treatment with Que, Kae, and Tam. These results are consistent with the actual induction profiles of terpenoids and flavonoids in human primary hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : qinkgolide B (GB)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : GB 50 microMDuration : Human primary hepatocytes (HL-#10 and HL-#13) in 24-well Biacoat plates were transfected with CYP2B6 reporter vactor (CYP2B6-2.2 kb) then treated with GB for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Result: EGb 761, GA and GB were associated with enhanced expression of CYP2B6-2.2 kb reporter gene, presumably through the endogenous pregnane X receptor (PXR) and constitutive androstane receptor (CAR), whereas no activation was observed after the treatment with Que, Kae, and Tam. These results are consistent with the actual induction profiles of terpenoids and flavonoids in human primary hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : bilobalide (BB)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : BB 50 microMDuration : Human primary hepatocytes (HL-#10 and HL-#13) in 24-well Biacoat plates were transfected with CYP2B6 reporter vactor (CYP2B6-2.2 kb) then treated with BB for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: EGb 761, GA and GB were associated with enhanced expression of CYP2B6-2.2 kb reporter gene, presumably through the endogenous pregnane X receptor (PXR) and constitutive androstane receptor (CAR), whereas no activation was observed after the treatment with Que, Kae, and Tam. These results are consistent with the actual induction profiles of terpenoids and flavonoids in human primary hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : quercetin (Que)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Que 25 mcg/mlDuration : Human primary hepatocytes (HL-#10 and HL-#13) in 24-well Biacoat plates were transfected with CYP2B6 reporter vactor (CYP2B6-2.2 kb) then treated with QUE for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: EGb 761, GA and GB were associated with enhanced expression of CYP2B6-2.2 kb reporter gene, presumably through the endogenous pregnane X receptor (PXR) and constitutive androstane receptor (CAR), whereas no activation was observed after the treatment with Que, Kae, and Tam. These results are consistent with the actual induction profiles of terpenoids and flavonoids in human primary hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
Part Used : ใบActivity : CYP2B6 INDUCTIONSolvent/Active Compound : kaempferol (Kae)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Kae 20 mcg/mlDuration : Human primary hepatocytes (HL-#10 and HL-#13) in 24-well Biacoat plates were transfected with CYP2B6 reporter vactor (CYP2B6-2.2 kb) then treated with Kae for 24 h.Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : NegativeRemark : Result: EGb 761, GA and GB were associated with enhanced expression of CYP2B6-2.2 kb reporter gene, presumably through the endogenous pregnane X receptor (PXR) and constitutive androstane receptor (CAR), whereas no activation was observed after the treatment with Que, Kae, and Tam. These results are consistent with the actual induction profiles of terpenoids and flavonoids in human primary hepatocytes.Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin
