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GINKGOACEAE Ginkgo biloba L.

Synonym

none ...

Thai / English name

แปะก๊วย*

[3-4] of 4 article(s) found

หน้า 1 2

[3] INDUCTION OF CYTOCHROME P450 3A BY THE GINKGO BILOBA EXTRACT AND BILOBALIDES IN HUMAN AND RAT PRIMARY HEPATOCYTES.
DENG Y,BI H,ZHAO L,ET AL.
DRUG METAB LETT 2008 Vol.2(1),60-6 412625 [Abstract]

Part Used : ไม่ระบุ
Activity : CYP3A INDUCTION

Solvent/Active Compound : Ginkgolides B

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 2 nanogram/mL

Duration : 72 h
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Ginkgolide B did not affect CYP3A protein expression in vitro.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP3A INDUCTION

Solvent/Active Compound : Ginkgolides B

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 nanogram/mL

Duration : 72 h
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Ginkgolide B did not affect CYP3A protein expression in vitro.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP3A INDUCTION

Solvent/Active Compound : Ginkgolides B

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 50 nanogram/mL

Duration : 72 h
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Ginkgolide B did not affect CYP3A protein expression in vitro.

Note : Data incomplete

[4] LIMITATIONS OF USING A SINGLE POSTDOSE MIDAZOLAM CONCENTRATION TO PREDICT CYP3A-MEDIATED DRUG INTERACTIONS.
PENZAK SR,BUSSE KH,ROBERTSON SM,ET AL.
J CLIN PHARMACOL 2008 Vol.48(6),671-80 423225 [Abstract]

Part Used : ใบ
Activity : CYP3A INDUCTION

Solvent/Active Compound : Ginkgo biloba extract (GBE)

Type of experiment : human
Type of animal : -

Type of study : Open trial

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Positive

Remark : The pupose of study was to assess the ability of single midazolam concentrations to predict midazolam AUC in the presence and absence of CYP3A modulation by GBE. Subjects received oral midazolam 8 mg before and after 28 days of GBE administration. The geometric mean raio (90% confidence intervals) of midazolam AUC 0-infinity - GBE / AUC 0-infinity pre - GBE was 0.66 (0.49-0.84) P = .03). Single midazolam concentrations between 2 and 5 hours correctly predicted the reduction in midazolam AUC following GBE exposure, but confidence intervals were generally wide.

Note : Data incomplete.

หน้า 1 2

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