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GINKGOACEAE Ginkgo biloba L.

Synonym

none ...

Thai / English name

แปะก๊วย*

[2-6] of 6 article(s) found

หน้า 1 2

[2] BIOACTIVE TERPENOIDS AND FLAVONOIDS FROM GINKGO BILOBA EXTRACT INDUCE THE EXPRESSION OF HEPATIC DRUG-METABOLIZING ENZYMES THROUGH PREGNANE X RECEPTOR, CONSTITUTIVE ANDROSTANE RECEPTOR, AND ARYL HYDROCARBON RECEPTOR-MEDIATED PATHWAYS.
LI L,STANTON JD,TOLSON AH,ET AL.
PHARM RES 2009 Vol.26(4),872-82 $23607 [Full]

Part Used : ใบ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : tamarixetin (Tam)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : Tam 10 mcg/ml

Duration : HepG2 cells were treated for 48 h with Tam
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Result: The results from human hepatocytes, flavonoids of EGb 761 are associated with potent induction of UGT1A1 and CYP1A2 mRNA expression in treated HepG2 cells, whereas typical activators of pregnane X receptor (PXR) (RIF 10 microM) and constitutive androstane receptor (CAR) (CITCO 1 microM) demonstrated no effects on UGT1A1 induction due to the negligible expression of these receptors in HepG2 cells.

Note : Abbreviations: AhR = Arylhydrocarbon receptor GA = Ginkgolide A, GB = Ginkgolide B, CAR = Constitutive androstane receptor, BB = Bilobalide, Que = Quercetin, Kae = Kaempferol, Tam = Tamarexetin

[3] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.(2),200-5 $56391 [Full]

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound :

Type of experiment : human
Type of animal : -

Type of study : non specified

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Non-specified
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Ritonavir
Dose/Conc.(drug) : -

Result : Negative

Remark : Most reports unconfirmed. No effect on CYP1A2, CYP3A4, CYP2E1, CYP2D6 activity in humans, but moderate inducer of CYP2C19. Interaction reported with omeprazole in Chinese patients and fatal seizures in a patient on antieplilepsy medication. Caution if taken with warfarin, antiplatelet dugs, alprazolam, donezepil, trazodone, anticancer drugs.

Note : Data from review, data incomplete.

[4] INDUCTION OF PROPRANOLOL METABOLISM BY GINKGO BILOBA EXTRACT EGB 761 IN RATS.
ZHAO L-Z,HUANG M,CHEN J,ET AL.
CURR DRUG METAB 2006 Vol.7(6),577-87 318757 [Abstract]

Part Used : -
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : EGB761 10 mg/kg/day

Duration : 10 days
Type of interaction : Pharmacokinetics

Interaction with drug : Propranolol*/Propanolol/Beta-propranolol
Dose/Conc.(drug) : -

Result : Equivocal

Remark :

Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11. - Data incomplete

Part Used : -
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : EGB761 100 mg/kg/day

Duration : 10 days
Type of interaction : Pharmacokinetics

Interaction with drug : Propranolol*/Propanolol/Beta-propranolol
Dose/Conc.(drug) : -

Result : Positive

Remark : Pretreatment of EGB761 at 100 mg/kg for 10 days significantly reduced the area uder the plasma concentration time curve (AUC) and maximum plasma concentration (Cmax) of propranolol, whereas those values of N-desisopropylpropranolol (NDP) were significantly increased.

Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11. - Data incomplete

[5] EFFECTS OF CYTOCHROME P450 ISOZYMES FROM HUMAN HEPATOCYTES ON INHIBITION OF PLATELET AGGREGATION INDUCED BY GINKGO EXTRACT.
QIU D,MAO Y,QIAO Y,ET AL.
ZHONGGUO LINCHUANG YAOXUE ZAZHI 2007 Vol.16(3),133-8 390873 [Abstract]

Part Used : ใบ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : Ginkgo biloba leaf ext. (GBE)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Alpha-naphthoflavon
Dose/Conc.(drug) : -

Result : Positive

Remark : The metabolism pathways involved for GBE were identified by preincubation of cryopreserved human primary hepatocytes (HPHs) with selective inhibitors of CYP1A2 (alpha-naphthoflavon).

Note : Result: GBE showed the inhibition of PAF-induced platelet aggregation with IC50 of 33 mg/L-1, 30% enhancement over the control. These effects of GBE were reduced significantly by selectively inhibiting CYP1A2 but CYP2B6, 2C19, 2E1 and 3A4. The inhibitive effects of GBE on PAF induced platelet aggregation are regulated by CYP1A2. Data incomplete.

[6] INDUCTION OF CYTOCHROME P450S BY TERPENE TRILACTONES AND FLAVONOIDS OF THE GINKGO BILOBA EXTRACT EGB 761 IN RATS.
DENG Y,BI H-C,ZHAO L-Z,ET AL.
XENOBIOTICA 2008 Vol.38(5),465-81 419428 [Abstract]

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : Bilobalide

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Bilobalide significantly induced the activity, protein, and mRNA expression of CYP3A1 and 1A2, and increased CYP 2E1 activity and CYP2B1/2 protein expression in a dose-dependent manner.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : Ginkgolide A

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Ginkgolide A, B, quercetin, and kaempferol did not affect CYP3A1, but induced CYP1A2 in a dose-dependent manner.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : Ginkgolide B

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Ginkgolide A, B, quercetin, and kaempferol did not affect CYP3A1, but induced CYP1A2 in a dose-dependent manner.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : quercetin

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Ginkgolide A, B, quercetin, and kaempferol did not affect CYP3A1, but induced CYP1A2 in a dose-dependent manner.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : CYP1A2 INDUCTION

Solvent/Active Compound : kaempferol

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : Ginkgolide A, B, quercetin, and kaempferol did not affect CYP3A1, but induced CYP1A2 in a dose-dependent manner.

Note : Data incomplete

หน้า 1 2

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