Synonym |
Thai / English name |
Part Used : ใบActivity : HEPATIC UDP GLUCORONOSYLTRANSFERASE ACTIVITY DECREASESolvent/Active Compound : 60% AcetoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 53 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Mycophenolic acid*/Mycophenolate/MMF/MPA/MofetilDose/Conc.(drug) : 240 micromolarResult : PositiveRemark : Results: Gingko and acid-hydrolyzed gingko extracts inhibited mycophenolic acid beta-D- glucoronide formation in human liver microsome with IC50 values of 84.3+/-11.6 and 20.9+/-3.6 microgram/ml, respectively. For a RDI of 240 mg, this would result in VDI of 2.9 and 11.4 l/dose for unhydrolyzed and acid hydrolyzed gingko extracts, respectively.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : ใบActivity : HEPATIC UDP GLUCORONOSYLTRANSFERASE ACTIVITY DECREASESolvent/Active Compound : 60% AcetoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 5.3 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Mycophenolic acid*/Mycophenolate/MMF/MPA/MofetilDose/Conc.(drug) : 240 micromolarResult : PositiveRemark : Results: Gingko and acid-hydrolyzed gingko extracts inhibited mycophenolic acid beta-D- glucoronide formation in human liver microsome with IC50 values of 84.3+/-11.6 and 20.9+/-3.6 microgram/ml, respectively. For a RDI of 240 mg, this would result in VDI of 2.9 and 11.4 l/dose for unhydrolyzed and acid hydrolyzed gingko extracts, respectively.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.
Part Used : ใบActivity : HEPATIC UDP GLUCORONOSYLTRANSFERASE ACTIVITY DECREASESolvent/Active Compound : 60% AcetoneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Dose in 0.53 L**Duration : -Type of interaction : PharmacokineticsInteraction with drug : Mycophenolic acid*/Mycophenolate/MMF/MPA/MofetilDose/Conc.(drug) : 240 micromolarResult : PositiveRemark : Results: Gingko and acid-hydrolyzed gingko extracts inhibited mycophenolic acid beta-D- glucoronide formation in human liver microsome with IC50 values of 84.3+/-11.6 and 20.9+/-3.6 microgram/ml, respectively. For a RDI of 240 mg, this would result in VDI of 2.9 and 11.4 l/dose for unhydrolyzed and acid hydrolyzed gingko extracts, respectively.Note : Type of experiment: *Human liver microsomal (HLM) **Working solutions were freshly prepared so that final herbal concentrations in screening incubations would represent the recommended daily intake of each extract in 53, 5.3, and 0.53 liters. Each herbal extract was coincubated at three concentrations with trifluoperazine (for UGT1A4), serotonin (for UGT1A6), and mycophenolic acid (for UGT1A9) and human liver microsome. Formation of trifluoperezine glucoronide, serotonin glucuronide, and mycophenolic acid beta-D- glucoronide were used as index reactions for activity of UGT1A4, UGT1A6, and UGT1A9 enzyme activities, respectively.