ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : DRUG INTERACTION

Solvent/Active Compound : Ginkgo biloba extract*

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 100 microgram/ml (Lot A)

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Mifepristone*/RU486

Dose/Conc.(drug) : 0.1 millimolar

Result : Negative

Remark : Gingko biloba extract did not alter hCAR or hPXR mRNA expression. Whereas the extract (100 mg/ml) increased CYP2B6 mRNA and CYP2B6-mediated bupropion hydroxylation, the increase was not attenuated by the co-treatment with a hGR antagonist (0.1 mM miferpristone: RU486).. The same pattern of response was also obtained for CYP3A4 mRNA and CYP3A-mediated testosterone 6b-hydroxylation. Therefore, Ginkgo biloba extract induces CYP2B6 (a hCAR target gene) and CYP3A4 (a hPXR target gene) by a hGR-independent mechanism.

Note : *Solvent/active compound: Ginkgo extract (Lot A) 200 micrgram/mL consist ginkogolide A, B, C, J and bilobalide as 2.2, 0.6, 2.8, 1.2 and 5.6 microgram/mL, respectively.

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