ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ใบ

Activity : CYP3A4 INDUCTION

Solvent/Active Compound : Ginkgo biloba leaf ext. (GBE)

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Itraconazole

Dose/Conc.(drug) : -

Result : Negative

Remark : The metabolism pathways involved for GBE were identified by preincubation of cryopreserved human primary hepatocytes (HPHs) with selective inhibitors of CYP3A4 (itraconazole).

Note : Result: GBE showed the inhibition of PAF-induced platelet aggregation with IC50 of 33 mg/L-1, 30% enhancement over the control. These effects of GBE were reduced significantly by selectively inhibiting CYP1A2 but CYP2B6, 2C19, 2E1 and 3A4. The inhibitive effects of GBE on PAF induced platelet aggregation are regulated by CYP1A2. Data incomplete.

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