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Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : ginkgolide AType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Hepatocytes were pretreated with ginkgolide A (at 1, 3, 10 and 30 mmol/L) for 48 h and then exposed to testosterone (250 mmol/L) for 30 min. Rifampin (10 mmol/L) and phenobarbital (2 mmol/L) were used as pos. controls.Duration : 30 min.Type of interaction : PharmacokineticsInteraction with drug : TestosteroneDose/Conc.(drug) : testosterone 250 mmol/LResult : PositiveRemark : Result: Compared with the vehicle control, ginkgolides A and B, at 30 mmol/L, significantly induced CYP3A protein expression (2.1- and 2-fold, resp.; both P < 0.01) and markedly induced CYP3A-mediated testosterone 6beta-hydroxylation (2.5-fold each; P < 0.05 for ginkgolide A; P > 0.05 for ginkgolide B). Quercetin had no apparent induction. Ginkgolide A and ginkgolide B can induce CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes at higher doses.Note : Data incomplete.
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : ginkgolide BType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Hepatocytes were pretreated with ginkgolide B (at 1, 3, 10 and 30 mmol/L) for 48 h and then exposed to testosterone (250 mmol/L) for 30 min. Rifampin (10 mmol/L) and phenobarbital (2 mmol/L) were used as pos. controls.Duration : 30 min.Type of interaction : PharmacokineticsInteraction with drug : TestosteroneDose/Conc.(drug) : testosterone 250 mmol/LResult : PositiveRemark : Result: Compared with the vehicle control, ginkgolides A and B, at 30 mmol/L, significantly induced CYP3A protein expression (2.1- and 2-fold, resp.; both P < 0.01) and markedly induced CYP3A-mediated testosterone 6beta-hydroxylation (2.5-fold each; P < 0.05 for ginkgolide A; P > 0.05 for ginkgolide B). Quercetin had no apparent induction. Ginkgolide A and ginkgolide B can induce CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes at higher doses.Note : Data incomplete.
Part Used : ไม่ระบุActivity : CYP3A INDUCTIONSolvent/Active Compound : quercetinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Hepatocytes were pretreated with quercetin (at 1, 3, 10 and 30 mmol/L) for 48 h and then exposed to testosterone (250 mmol/L) for 30 min. Rifampin (10 mmol/L) and phenobarbital (2 mmol/L) were used as pos. controls.Duration : 30 min.Type of interaction : PharmacokineticsInteraction with drug : TestosteroneDose/Conc.(drug) : testosterone 250 mmol/LResult : NegativeRemark : Result: Compared with the vehicle control, ginkgolides A and B, at 30 mmol/L, significantly induced CYP3A protein expression (2.1- and 2-fold, resp.; both P < 0.01) and markedly induced CYP3A-mediated testosterone 6beta-hydroxylation (2.5-fold each; P < 0.05 for ginkgolide A; P > 0.05 for ginkgolide B). Quercetin had no apparent induction. Ginkgolide A and ginkgolide B can induce CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes at higher doses.Note : Data incomplete.
