ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : Ginkgolide B (GB)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Intravenous

Dose/Conc.(herb) : 10 mg/kg

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Probenecid*/Benemid

Dose/Conc.(drug) : 300 mg/kg

Result : Positive

Remark : The systemic exposure in the group treated with probenecid (p<0.05 vs control) was significantly raised to 14.75+/-1.328 microgram/mL/h. Specifically, probenecid could significantly decreased the CLtotal of GB from 1.17+/-0.331 to 0.596+/-0.0573 L/h/kg. Albeit probenecid could significantly reduce GB clearance and volume of distribution (V) when compared with control group, the elimination half-time (t1/2lambda) of each group remained close to each other, fitted as 2.04+/-0.376, and 2.34+/-0.851, for the control and probenecid, respectively.

Note : CLtotal = total plasma clearance

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