ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : OATP (ORGANIC ANION TRANSPORTER PROTEIN) INHIBITION

Solvent/Active Compound : Ginkgolide B (GB)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Intravenous

Dose/Conc.(herb) : 10 mg/kg

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Probenecid*/Benemid

Dose/Conc.(drug) : 300 mg/kg

Result : Positive

Remark : Without the presence of inhibitors, the accumulative excretion of GB was calculated at around 962.2 microgram. Without the presence of inhibitors, the accumulative excretion of GB was calculated at around 962.2 microgram, while the excretion was significantly decreased to 370.3 microgram when pretreated with probenecid (potential inhibitor of organic anion transporter/organic anion transporting polypeptides). The probenecid could exert obvious and strong inhibition from the very beginning afer dosing.

Note : CLtotal = total plasma clearance

---