Part Used : ใบ
Activity : ANTIISCHEMIC EFFECT
Solvent/Active Compound : EGb761 (a standard form of the extract of Ginkgo biloba leaf)
Type of experiment : in vivo
Type of animal : other
N(Total) : -
N(Treatment) : -
Route : Other
Dose/Conc.(herb) : The gerbils fed a standard diet were intragastrically given EGb761 (100 mg/kg/day) for one week and the gerbils were injected with FK506 (0.5 mg/kg), 30 min before MCAO*.
Duration : -
Type of interaction : Pharmacodynamics
Interaction with drug : Tacrolimus
Dose/Conc.(drug) : Tacrolimus 0.5 mg/kg (FK506)
Remark : Result: The total infarct volumes of the four treated groups either EGb761 alone or in combination with drugs were lower than the control group by 36.1% (EGb761 alone), 40.3% (EGb761 + MgSO4), 35.3% (EGb761 + FK506), and 56.4% (EGb761 + MK-801), respectively (p < 0.01). The main affected areas of the brain in the four treated groups were significantly focused between 4 and 6 mm from the frontal pole, when compared to the control goups (p < 0.01). All animals in the five groups had infarctions in both cortex and subcortex. These results indicate that long-term pre-treatment of EGb761 administered either alone or in combination with drugs significantly effective neuroprotection on infarct volume in gerbil ischemic brains.
Note : Type of animal: Gerbil.
Rout: intragastric.
*The infarct volume of male gerbils' brain induced by unilateral middle cerebral artery occlusion (MCAO).
