Part Used : ใบ
Activity : DRUG INTERACTION
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 14*
N(Treatment) : 7**
Route : Oral administration
Dose/Conc.(herb) : Voriconazole 200 mg after administration of Ginkgo biloba 120 mg twice daily.
Duration : 12 days
Type of interaction : Pharmacokinetics
Interaction with drug : Voriconazole
Dose/Conc.(drug) : -
Remark : * Healthy and nonsmoking volunteers.
** CYP2C19 extensive metabolizers (2C19*1/2C19*1).
Results: For extensive metabolizers, the median value for voriconazole area under the plasma concentration time cruve from zero to infinity (AUC0-infinity) was 5.17 microgram/mL after administration of voriconazole alone and 4.28 microgram/mL after voriconazole with Ginkgo biloba (p>0.05). The other pharmacokinetic parameters of voriconazole such as AUC0-24, time to reach maximum concentration, half-life, and apparent clearance also did not change significantly for expensive metabolizers in the presence of Ginkgo biloba.
Note : - 2 phase randomized crossover study with 4 weeks washout between phases.
- Data incomplete.
