| Synonym |
| Thai / English name |
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 2 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : There were no significant changes observed in the pharmacokinetic parameters of S- or R-warfarin in healthy male subjects following treatment with ginkgo or ginger. The urinary excretion rate of S-7-hydroxywarfarin after administration of warfarin alone was no significant difference following treatment with either ginkgo or ginger.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : MaleAge : 20-36 yrsRoute : Oral administrationDose/Conc.(herb) : 2 tablets x 3 times dailyDuration : 1 week with at least 14-day washoutType of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : There were no significant changes observed in the pharmacokinetic parameters of S- or R-warfarin in healthy male subjects following treatment with ginkgo or ginger. The urinary excretion rate of S-7-hydroxywarfarin after administration of warfarin alone was no significant difference following treatment with either ginkgo or ginger.Note : Each ginger tablet containing 0.4 g of ginger rhizome powder Each Gingko tablet equivalent to 2 g of Ginkgo biloba leaf (9.6 mg of ginkgo flavonglycosides, 2.4 mg of ginkgolides and bilobalide)
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 24N(Treatment) : 24Sex : MaleAge : 26 +/- 5 yearsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : 25 mgResult : NegativeRemark : Coadministration with either ginkgo or ginger with warfarin did not affect the pharmacokinetics or pharmacodynamics of S-warfarin.Note : Type of clinical study: randomized, open-label, controlled, 3-treatment, and 3-sequence crossover studies with at least a 14-day washout period between study periods of dosing. Subjects: healthy male subjects received a single 25 mg dose warfarin with or without pretreatment with Commission E19 recommended daily doses of St John's wort, Asian ginseng (Panax ginseng), ginkgo (Ginkgo biloba), or ginger from commercially available products of known quality.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 24N(Treatment) : 24Sex : MaleAge : 26 +/- 5 yearsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : WarfarinDose/Conc.(drug) : 25 mgResult : NegativeRemark : Coadministration with either ginkgo or ginger with warfarin did not affect the pharmacokinetics or pharmacodynamics of S-warfarin.Note : Type of clinical study: randomized, open-label, controlled, 3-treatment, and 3-sequence crossover studies with at least a 14-day washout period between study periods of dosing. Subjects: healthy male subjects received a single 25 mg dose warfarin with or without pretreatment with Commission E19 recommended daily doses of St John's wort, Asian ginseng (Panax ginseng), ginkgo (Ginkgo biloba), or ginger from commercially available products of known quality.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 11,424N(Treatment) : -Sex : Both sexAge : >/=18 yearsRoute : Oral administrationDose/Conc.(herb) : -Duration : 2000-2001Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Ginkgo biloba was associated with the potential for major bleeding due to combined use with acetylsalicylic acid (ASA) or warfarin.Note : Subjects: Of the adult National population Health Survey respondents (n=11,424), 9.3% reported the use of at least 1 natural health product in the past 2 days in 2000-2001.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 250N(Treatment) : 101Sex : Both sexAge : 69+/-10 yrs.Route : Oral administrationDose/Conc.(herb) : Consumption of herbs at least 4 times per weekDuration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Consumption of herbs at least 4 times per week was associated with suboptimal anticoagulation control with warfarin. Patients treated with warfarin should not only be aware of the intake of herbal drugs but also of foods with herbal ingredients such as garlic, ginger, and papaya.Note : Patients with atrial fibrillation (AF) who were prescribed warfarin therapy for at least 6 months before the study were recruited from the medical and cardiac clinics.
