Part Used : ใบ
Activity : DRUG INTERACTION
Solvent/Active Compound : Ginkgo biloba extraction (GBE)
Type of experiment : human
Type of animal : -
Type of study : Open trial
N(Total) : 10
N(Treatment) : 10
Route : Oral administration
Dose/Conc.(herb) : GBE intake 360 mg/d
Duration : 28 days
Type of interaction : Pharmacokinetics
Interaction with drug : Tolbutamide
Dose/Conc.(drug) : -
Remark : - Tolbutamide 125 mg were orally administered to 10 male healthy volunteers before and after GBE intake, and received 75 g glucose after the dosing of tolbutamide.
- The area under concentration vs. time curve (AUC0-alpha) for tolbutamide after GBE intake was slightly but significantly (16%) lower than that before GBE intake. Concomitantly, GBE tended to attenuate AUC0-2 of blood glucose-lowering effect of tolbutamide.