ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ใบ

Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : Ginkgo biloba extraction (GBE)

Type of experiment : human

Type of animal : -

Type of study : Open trial

N(Total) : 10

N(Treatment) : 10

Sex : Male

Age : -

Route : Oral administration

Dose/Conc.(herb) : GBE intake 360 mg/d

Duration : 28 days

Type of interaction : Pharmacokinetics

Interaction with drug : Tolbutamide

Dose/Conc.(drug) : -

Result : Positive

Remark : - Tolbutamide 125 mg were orally administered to 10 male healthy volunteers before and after GBE intake, and received 75 g glucose after the dosing of tolbutamide. - The area under concentration vs. time curve (AUC0-alpha) for tolbutamide after GBE intake was slightly but significantly (16%) lower than that before GBE intake. Concomitantly, GBE tended to attenuate AUC0-2 of blood glucose-lowering effect of tolbutamide.

Note : - Data incomplete

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