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| Thai / English name |
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : G. biloba extract (GBE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : GBE 10 mg/kgDuration : 5 daysType of interaction : PharmacokineticsInteraction with drug : Theophylline*/AminophyllineDose/Conc.(drug) : 10 mg/kg (IV)Result : PositiveRemark : Results: pretreatment of rats with GBE resulted in an increase in the total clearance of theophylline of about 30% (GBE 10 mg/kg, P<0.05) and 70% (GBE 100 mg/kg, P<0.01) compared with the control group after intravenous administration of theophylline (10 mg/kg).
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : G. biloba extract (GBE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : GBE 100 mg/kgDuration : 5 daysType of interaction : PharmacokineticsInteraction with drug : Theophylline*/AminophyllineDose/Conc.(drug) : 10 mg/kg (IV)Result : PositiveRemark : Results: pretreatment of rats with GBE resulted in an increase in the total clearance of theophylline of about 30% (GBE 10 mg/kg, P<0.05) and 70% (GBE 100 mg/kg, P<0.01) compared with the control group after intravenous administration of theophylline (10 mg/kg).
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : G. biloba extract (GBE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : GBE 10 mg/kgDuration : 5 daysType of interaction : PharmacokineticsInteraction with drug : Theophylline*/AminophyllineDose/Conc.(drug) : 10 mg/kg (PO)Result : PositiveRemark : Results: The oral clearance was significantly increased following pretreatment with GBE (10 mg/kg vs control, P < 0.05; 100 mg/kg vs control, P < 0.01). The AUC0-24 h was reduced by 16.3% following pretreatment with GBE (10 mg/kg), although the difference was not statistically significant. However, the AUC0-24 h was significantly reduced by pretreatment with GBE (100 mg/kg vs control, P < 0.01). The Cmax of theophylline was significantly reduced by pretreatment with GBE (100 mg/kg va control, P <0.05), but the time to reach maximum concentration after treatment was unchanged.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : G. biloba extract (GBE)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : GBE 100 mg/kgDuration : 5 daysType of interaction : PharmacokineticsInteraction with drug : Theophylline*/AminophyllineDose/Conc.(drug) : 10 mg/kg (PO)Result : PositiveRemark : Results: The oral clearance was significantly increased following pretreatment with GBE (10 mg/kg vs control, P < 0.05; 100 mg/kg vs control, P < 0.01). The AUC0-24 h was reduced by 16.3% following pretreatment with GBE (10 mg/kg), although the difference was not statistically significant. However, the AUC0-24 h was significantly reduced by pretreatment with GBE (100 mg/kg vs control, P < 0.01). The Cmax of theophylline was significantly reduced by pretreatment with GBE (100 mg/kg va control, P <0.05), but the time to reach maximum concentration after treatment was unchanged.
