ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : -

Activity : EFFECTS ON PHARMACOKINETIC

Solvent/Active Compound : The standard Ginkgo biloba extraction (EGB761)

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : EGB761 100 mg/kg/day

Duration : 10 days

Type of interaction : Pharmacokinetics

Interaction with drug : Propranolol*/Propanolol/Beta-propranolol

Dose/Conc.(drug) : -

Result : Positive

Remark : Pretreatment of EGB761 at 100 mg/kg for 10 days significantly reduced the area uder the plasma concentration time curve (AUC) and maximum plasma concentration (Cmax) of propranolol, whereas those values of N-desisopropylpropranolol (NDP) were significantly increased.

Note : - A single oral dose of propranolol (10 mg/kg) was administered on day 11. - Data incomplete

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