Part Used : ใบ
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 8
N(Treatment) : 8
Sex : Male
Age : 24-45 (29+/-3 years)
Route : Oral administration
Dose/Conc.(herb) : two capsules containing Ginkgo biloba leaf extract (GBE) (a total GBE dose of 240 mg: general daily dose in human)
Duration : 2 weeks
Type of interaction : Pharmacokinetics
Interaction with drug : Nifedipine
Dose/Conc.(drug) : 10 mg
Remark : Simultaneous oral ingestion of GBE (240 mg) did not significantly affect any of the mean pharmacokinetic parameters of either nifedipine (NFP) or dehydronifedipine, a major metabolite of NEP, after oral administration of NFP (10 mg). However, the maximal plasma NFP concentrations in 2 subjects were approximately doubled by GBE.
Note : Subjects : Healthy volunteers
Accordingly, it was concluded that GBE and NEP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NEP concomitantly with GBE to humans.
