Part Used : ใบ
Activity : ALGESIC ACTIVITY
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 8 (M/F=8/-)
N(Treatment) : 8 (M/F=8/-)
Sex : Male
Age : 24-45 (29+/-3 years)
Route : Oral administration
Dose/Conc.(herb) : two capsules containing Ginkgo biloba leaf extract (GBE) (a total GBE dose of 240 mg: general daily dose in human)
Duration : 2 weeks
Type of interaction : Pharmacodynamics
Interaction with drug : Nifedipine
Dose/Conc.(drug) : 10 mg
Remark : 2 subjects were approximately doubled by GBE, and they had severer and longer-lasting headaches with GBE than without GBE, with dizziness or hot flushes in combination with GBE. The mean heart rate after oral administration of NFP with GBE tended to be faster than that without GBE at every time point.
Note : Subjects : Healthy volunteers
Accordingly, it was concluded that GBE and NEP should not be simultaneously ingested as much as possible, and careful monitoring is needed when administering NEP concomitantly with GBE to humans.
