Part Used : -
Activity : DRUG INTERACTION
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyA
Dose/Conc.(drug) : -
Note : - Cyclosporin was administered orally and i.v. to rats with and without an oral dose of ginkgo or onion in crossover designs.
- Oral coadministration of ginkgo and onion significantly decreased the Cmax of cyclosporine by 62% and 60%, and reduced the AUC0-t by 51% and 68%, respectively, whereas no influence observed when cyclosporine was given by i.v.
- Data incomplete.