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EUPHORBIACEAE Phyllanthus amarus Schumach. & Thonn.

Synonym

EUPHORBIACEAE Phyllanthus nanus Hook.f.
EUPHORBIACEAE Phyllanthus niruri Thw.

Thai / English name

ลูกใต้ใบ*

[1-2] of 2 article(s) found

หน้า 1

[1] SYNERGISTIC EFFECT OF SILYMARIN AND STANDARDIZED EXTRACT OF PHYLLANTHUS AMARUS AGAINST CCI4-INDUCED HEPATOTOXICITY IN RATTUS NORVEGICUS.
YADAV NP,PAL A,SHANKER K,ET AL.
PHYTOMEDICINE 2008 Vol.15(12),1053-61 $21682 [Full]

Part Used : ทั้งต้น
Activity : DRUG INTERACTION

Solvent/Active Compound : standardized extract of Phyllanthus amarus

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Intraperitoneal
Dose/Conc.(herb) : silymarin (50 mg/kg b.w.) + Phyllanthus amarus aqueous extract (50 mg/kg b.w.)

Duration : 6 days
Type of interaction : Pharmacodynamics

Interaction with drug : Silymarin*/Silybin B
Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : Result: The combination of silymarin and Phyllanthus amarus showed synergistic effect for hepatoprotection and silymarin with ethanolic extract of P. amarus showed better activity due to the higher concentration of phyllanthin in ethanolic extract in comparison to aqueous extract of P. amarus as estimated by HPLC.

Part Used : ทั้งต้น
Activity : DRUG INTERACTION

Solvent/Active Compound : standardized extract of Phyllanthus amarus

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Intraperitoneal
Dose/Conc.(herb) : silymarin (50 mg/kg b.w.) + Phyllanthus amarus ethanolic extract (50 mg/kg b.w.)

Duration : 6 days
Type of interaction : Pharmacodynamics

Interaction with drug : Silymarin*/Silybin B
Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : Result: The combination of silymarin and Phyllanthus amarus showed synergistic effect for hepatoprotection and silymarin with ethanolic extract of P. amarus showed better activity due to the higher concentration of phyllanthin in ethanolic extract in comparison to aqueous extract of P. amarus as estimated by HPLC.

[2] SYNERGISTIC EFFECT OF SILYMARIN AND STANDARDIZED EXTRACT OF PHYLLANTHUS AMARUS AGAINST CCL4-INDUCED HEPATOTOXICITY IN RATTUS NORVEGICUS.
YADAV NP,PAL A,SHANKER K,ET AL.
PHYTOMEDICINE 2008 Vol.15(12),1053-61 443626 [Abstract]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : P. amarus aqueous extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : P. amarus aqueous extract 50 mg/kg + silymarin 50 mg/kg

Duration : 6 days
Type of interaction : Pharmacodynamics

Interaction with drug : Silymarin*/Silybin B
Dose/Conc.(drug) : -

Result : Positive

Remark : Results: The combination of silymarin and Phyllanthus amarus showed synergistic effect for hepatoprotection and silymarin with ethanolic extract of P. amarus showed better activity due to the higher concentration of phyllanthin in ethanolic extract in comparison to aqueous extract of P. amarus as estimated by HPLC.

Note : Data incomplete

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : P. amarus ethanolic extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : P. amarus aqueous extract 50 mg/kg + silymarin 50 mg/kg

Duration : 6 days
Type of interaction : Pharmacodynamics

Interaction with drug : Silymarin*/Silybin B
Dose/Conc.(drug) : -

Result : Positive

Remark : Results: The combination of silymarin and Phyllanthus amarus showed synergistic effect for hepatoprotection and silymarin with ethanolic extract of P. amarus showed better activity due to the higher concentration of phyllanthin in ethanolic extract in comparison to aqueous extract of P. amarus as estimated by HPLC.

Note : Data incomplete

หน้า 1

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