Part Used : เมล็ด
Activity : P-GLYCOPROTEIN INHIBITION
Solvent/Active Compound : procyanidin
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Paclitaxel*/Taxol/PTX
Dose/Conc.(drug) : -
Remark : Grape seed procyanidin reversed MDR by inhibiting the function and expression of p-glycoprotein via inhibition of NF-kappaB and gammaB-1 translocation intonucleus through dephosphorylation of AKT and ERK1/2 respectively.