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Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : grape juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : a single oral dose of diltiazem 180 mg with 200 mL of grape juiceDuration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : DiltiazemDose/Conc.(drug) : 180 mgResult : NegativeRemark : Results: The 90% Cl of the Cmax ratios for grape juice/water were 93.91 - 103.13. Similarly, the 90% Cl of the AUC0-infinity ratios for grape juice vs. water were 88.56 - 104.06. Since these values fall within the bioequivalence criteria of 80 - 120% limits, the study demonstrates absence of interaction of diltiazem with grape juice.Note : *Subject total: Subjects were healthy volunteers. Conclusions: There is no significant influence of grape juice or orange juice on the pharmacokinetics and pharmacodynamics of diltiazem. Data incomplete.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : grape juiceType of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12*N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : a single oral dose of diltiazem 180 mg with 200 mL of grape juiceDuration : -Type of interaction : P.Kinetics & P.DynamicsInteraction with drug : DiltiazemDose/Conc.(drug) : 180 mgResult : NegativeRemark : Results: The 90% Cl of the Cmax ratios for grape juice/water were 93.91 - 103.13. Similarly, the 90% Cl of the AUC0-infinity ratios for grape juice vs. water were 88.56 - 104.06. Since these values fall within the bioequivalence criteria of 80 - 120% limits, the study demonstrates absence of interaction of diltiazem with grape juice.Note : *Subject total: Subjects were healthy volunteers. Conclusions: There is no significant influence of grape juice or orange juice on the pharmacokinetics and pharmacodynamics of diltiazem. Data incomplete.
