Part Used : เมล็ด
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : 1 weeks
Type of interaction : Pharmacokinetics
Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -
Remark : Although single treatments with green tea exts. or grape seed ext. had negligible effects, 1 wk of treatment with them resulted in a significant increase in the ke of i.v. administered midazolam (MDZ), indicating the induction of CYP3A in the liver.