ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เมล็ด

Activity : CYP3A4 INDUCTION

Solvent/Active Compound : -

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : 1 weeks

Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum

Dose/Conc.(drug) : -

Result : Positive

Remark : Although single treatments with green tea exts. or grape seed ext. had negligible effects, 1 wk of treatment with them resulted in a significant increase in the ke of i.v. administered midazolam (MDZ), indicating the induction of CYP3A in the liver.

Note : Data incomplete

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