ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เมล็ด

Activity : DRUG INTERACTION

Solvent/Active Compound : grape seed extract

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 100 microgram/ml

Duration : 30 minutes

Type of interaction : Pharmacokinetics

Interaction with drug : Docetaxel*/Taxotere

Dose/Conc.(drug) : -

Result : Positive

Remark : - Details of the standardized Grape seed extracts: 5.08% Epigallocatechin, 0.93% Catechin, 6.30% Epicatechin, 0.02% Epigallocatechin gallate, 0.03% Epicatechin gallate. - Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 92.0% and IC50 values of that inhibit CYP3A4-mediated metabolism of docetaxel = 15.3 microgram/ml, 95% Cl: 10.5-22.3.

Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).

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