Part Used : เมล็ด
Activity : CYP3A4 INHIBITION
Solvent/Active Compound : grape seed extract
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 100 microgram/ml
Duration : 30 minutes
Type of interaction : Pharmacokinetics
Interaction with drug : Docetaxel*/Taxotere
Dose/Conc.(drug) : -
Remark : - Details of the standardized Grape seed extracts: 5.08% Epigallocatechin, 0.93% Catechin, 6.30% Epicatechin, 0.02% Epigallocatechin gallate, 0.03% Epicatechin gallate.
- Results: The degree of CYP3A4 inhibition of Ginkgo biloba was 92.0% and IC50 values of that inhibit CYP3A4-mediated metabolism of docetaxel = 15.3 microgram/ml, 95% Cl: 10.5-22.3.
Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).