Part Used : เมล็ด
Activity : DRUG INTERACTION
Solvent/Active Compound : hydrogel (mucilage)
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : solid dispersion equivalent to 50 mg in 200 mL water
Duration : single dose
Type of interaction : Pharmacokinetics
Interaction with drug : Carbamazepine*/CBZ
Dose/Conc.(drug) : -
Remark : The Gel was found to be the efficient solubility and bioavailability enhancer for carbamazepine.
Note : Gel = mucilage isolated from the seeds of Ocimum basilicum.
Solid dispersion of carbamazepine was prepared by adopting co grinding/ comicronization method. Carbamazepine (CBZ) was co- ground in colloid mill with Gel (in suitable proportion to obtain solid dispersion of CBZ: dried mucilage in 1:1 ratio).