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ARALIACEAE Panax quinquefolium L.

Synonym

none ...

Thai / English name

โสมอเมริกัน*

[1-2] of 2 article(s) found

หน้า 1

[1] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.2(),200-5 $29296 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenosides

Type of experiment : human
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : P. quinquefolius reduced effects of warfarin in healthy volunteers, but P. ginseng had no effect.

Note : Data incomplete, data from review article.

[2] INTERACTIONS BETWEEN HERBAL AND CONVENTIONAL MEDICINES: THE ROLE OF CYTOCHROME P450 ENZYMES AND P-GLYCOPROTEIN.
WILLIAMSON EM
PHARMACOLOGYONLINE 2006 Vol.(2),200-5 $56391 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : non specified

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Non-specified
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Warfarin
Dose/Conc.(drug) : -

Result : Positive

Remark : Suspected potentiation of phenelzine and nifedipine (a CYP3A4 substrate) in animal study. Enzyme-selective effects on other CYP's depend on nature of extract. Ginsenosides inhibit P-gp at high concentrations. Avoid with MAOl's, nifedipine, and in cancer chemotherapy. P. quinquefolius reduced effects of warfarin in healthy volunteers, but P. ginseng had no effect.

Note : Data from review, data incomplete.

หน้า 1

EN

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