Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION
Solvent/Active Compound : Ginsenosides
Type of experiment : in vivo
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Nifedipine
Dose/Conc.(drug) : -
Remark : Suspected potentiation of phenelzine and nifedipine (a CYP3A4 substrate) in animal study. Enzyme-selective effects on other CYP's depend on nature of extract. Ginsenosides inhibit P-gp at high concentrations. Avoid with MAOI's nifedipine, and in cancer chemotherapy.
Note : Data incomplete, data from review article.