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| Thai / English name |
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : 30 minutesType of interaction : PharmacokineticsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Ginseng extracts: 0.44% Eleutheroside E, 0.25% Eleutheroside B. - Results: The degree of CYP3A4 inhibition of Ginseng was 16.8%.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : 20(S)-ginsenoside F1 (20(S)-GF1), ginsenoside Rh1(Rh1)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 micromolarsDuration : -Type of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark : Result: The inhibitory effects on P-gp mediated digoxin transport were investigated in MDR1-MDCKII cells. Emodin, 18 beta-GA, DAG, and 20 (S)-GF1 exhibited significant inhibition (> 50%) on P-gp. However, the isomers or analogs of the 4 herbal constituents (chrysophanol, 18alpha-GA, AG, and Rh1) and the remaining tested compounds relatively weak inhibition on digoxin transport in this cell model. The concentraion-dependent inhibition on P-gp-mediated digoxin transport was further investigated for emodin, 18beta-GA, DAG, and 20(S)-GF1. Emodin was the strongest herbal inhibitor of P-gp, followed by 18beta-GA, 20(S)-GF1 and DAG. Consistent with the data obtained from MDR1-MDCKII cells, emodin, 18 beta-GA, DAG, and 20(S)-GF1 significantly inhibited digoxin transport (>50%), while chrysophanol, 18alpha-GA, AG, and Rh1 showed no effects or relatively weak inhibition on P-gp.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : PhenelzineDose/Conc.(drug) : -Result : PositiveRemark : Suspected potentiation of phenelzine and nifedipine (a CYP3A4 substrate) in animal study. Enzyme-selective effects on other CYP's depend on nature of extract. Ginsenosides inhibit P-gp at high concentrations. Avoid with MAOl's, nifedipine, and in cancer chemotherapy. P. quinquefolius reduced effects of warfarin in healthy volunteers, but P. ginseng had no effect.Note : Data from review, data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : in vivoType of animal : otherType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : NifedipineDose/Conc.(drug) : -Result : PositiveRemark : Suspected potentiation of phenelzine and nifedipine (a CYP3A4 substrate) in animal study. Enzyme-selective effects on other CYP's depend on nature of extract. Ginsenosides inhibit P-gp at high concentrations. Avoid with MAOl's, nifedipine, and in cancer chemotherapy. P. quinquefolius reduced effects of warfarin in healthy volunteers, but P. ginseng had no effect.Note : Data from review, data incomplete.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : Suspected potentiation of phenelzine and nifedipine (a CYP3A4 substrate) in animal study. Enzyme-selective effects on other CYP's depend on nature of extract. Ginsenosides inhibit P-gp at high concentrations. Avoid with MAOl's, nifedipine, and in cancer chemotherapy. P. quinquefolius reduced effects of warfarin in healthy volunteers, but P. ginseng had no effect.Note : Data from review, data incomplete.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : red ginseng powderType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Enflurane*/Methylflurether/Efrane/EthraneDose/Conc.(drug) : -Result : NegativeRemark : - Twenty rats were divided into 4 groups (n=5) as follows: group 1 - control, group 2-4 fed with red ginseng powder 15, 75 and 200 mg/kg/day, respectively. Red ginseng powder was dissolved in deionized water based on 20 ml/rat/day. After 2 weeks of drinking ad libitum they were killed and collected liver microsomes for measurement of protein content and anesthetic defluorination activity. - The rates of enflurane and methoxyflurane defluorination by rat liver microsomes determined by incubation of 10 microliters of each anesthetic with 5 mg of microsomal protein.Note : There were no statistically significant differences in hepatic microsomal cytochrome p-450 content or defluorination of enflurane and methoxyflurane between control and experimental groups using either red ginseng extract or powder.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : red ginseng powderType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : MethoxyfluraneDose/Conc.(drug) : -Result : NegativeRemark : - Twenty rats were divided into 4 groups (n=5) as follows: group 1 - control, group 2-4 fed with red ginseng powder 15, 75 and 200 mg/kg/day, respectively. Red ginseng powder was dissolved in deionized water based on 20 ml/rat/day. After 2 weeks of drinking ad libitum they were killed and collected liver microsomes for measurement of protein content and anesthetic defluorination activity. - The rates of enflurane and methoxyflurane defluorination by rat liver microsomes determined by incubation of 10 microliters of each anesthetic with 5 mg of microsomal protein.Note : There were no statistically significant differences in hepatic microsomal cytochrome p-450 content or defluorination of enflurane and methoxyflurane between control and experimental groups using either red ginseng extract or powder.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : red ginseng powderType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 62.5 mg/kg/dayDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : Enflurane*/Methylflurether/Efrane/EthraneDose/Conc.(drug) : -Result : NegativeRemark : Red ginseng extract was dissolved in 0.9% saline (0.5 ml) and administered with 22G gavage needle three times a day for three days. In the morning of fourth day, rats were administered enflurane 0.6 microliters/g i.p.Note : There were no statistically significant differences in hepatic microsomal cytochrome p-450 content or defluorination of enflurane and methoxyflurane between control and experimental groups using either red ginseng extract or powder.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : red ginseng powderType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 125 mg/kg/dayDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : Enflurane*/Methylflurether/Efrane/EthraneDose/Conc.(drug) : -Result : NegativeRemark : Red ginseng extract was dissolved in 0.9% saline (0.5 ml) and administered with 22G gavage needle three times a day for three days. In the morning of fourth day, rats were administered enflurane 0.6 microliters/g i.p.Note : There were no statistically significant differences in hepatic microsomal cytochrome p-450 content or defluorination of enflurane and methoxyflurane between control and experimental groups using either red ginseng extract or powder.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : red ginseng powderType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 250 mg/kg/dayDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : Enflurane*/Methylflurether/Efrane/EthraneDose/Conc.(drug) : -Result : NegativeRemark : Red ginseng extract was dissolved in 0.9% saline (0.5 ml) and administered with 22G gavage needle three times a day for three days. In the morning of fourth day, rats were administered enflurane 0.6 microliters/g i.p.Note : There were no statistically significant differences in hepatic microsomal cytochrome p-450 content or defluorination of enflurane and methoxyflurane between control and experimental groups using either red ginseng extract or powder.
