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ARALIACEAE Panax ginseng C.A. Mey.

Synonym

none ...

Thai / English name

โสม*

[15-15] of 38 article(s) found

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[15] EVALUATION OF THE IN VITRO/IN VIVO DRUG INTERACTION POTENTIAL OF BST204, A PURIFIED DRY EXTRACT OF GINSENG, AND ITS FOUR BIOACTIVE GINSENOSIDES THROUGH CYTOCHROME P450 INHIBITION/INDUCTION AND UDP-GLUCURONOSYLTRANSFERASE INHIBITION.
YU FEN ZHENG,SOO HYEON BAE,EU JIN CHOI,ET AL.
FOOD CHEM TOXICOL 2014 Vol.68(),117-27 $50850 [Full]

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside S-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 0.1 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.02 +/- 0.0311, 1.11 +/- 0.212, and 0.988 +/- 0.0181, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside S-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 1 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.02 +/- 0.0618, 1.13 +/- 0.0754, and 0.979 +/- 0.00715, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside S-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 10 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.940 +/- 0.0522, 1.08 +/- 0.150, and 0.979 +/- 0.0980, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside R-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 0.1 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.989 +/- 0.112, 1.03 +/- 0.164, and 0.872 +/- 0.0500, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside R-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 1 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.989 +/- 0.0884, 1.04 +/- 0.144, and 0.849 +/- 0.0706, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside R-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 10 microgram/mL ginsenoside S-Rg3 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.09 +/- 0.0739, 1.03 +/- 0.0516, and 0.846 +/- 0.0438, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside S-Rh2

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 0.1 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.02 +/- 0.014, 1.07 +/- 0.0285, and 0.961 +/- 0.0320, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside S-Rh2

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 1 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.959 +/- 0.0106, 1.23 +/- 0.211, and 0.885 +/- 0.0419, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside S-Rh2

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 10 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.03 +/- 0.0160, 1.08 +/- 0.400, and 0.835 +/- 0.0347, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside R-Rh2

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Smoking
Dose/Conc.(herb) : 0.1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 01 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.946 +/- 0.0442, 0.987 +/- 0.112, and 0.910 +/- 0.0513, respectively.

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