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ARALIACEAE Panax ginseng C.A. Mey.

Synonym

none ...

Thai / English name

โสม*

[14-15] of 38 article(s) found

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[14] EFFECTS OF SUPERFINE GRINDING ON PHYSICOCHEMICAL AND ANTIOXIDANT PROPERTIES OF LYCIUM BARBARUM POLYSACCHARIDES.
MIN ZHANG,FANG WANG,RUI LIU,ET AL.
LWT - FOOD SCIENCE AND TECHNOLOGY 2014 Vol.58(),594-601 $50580 [Full]

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : BST204

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 400 mg/kg

Duration : **
Type of interaction : Non-specified

Interaction with drug : Irinotecan*/Camptothecin-11/CPT-11
Dose/Conc.(drug) : -

Result : Negative

Remark : - BST204 and irinotecan co-administration. Thirty mimutes prior to irinotecan administration, BST204 (suspended in distilled water) at a dose of 400 mg (in 10mL)/kg was orally administered. Then, Irinotecan (dissolved in DMSO: 0.9% NaCl injectable solution, v/v = 5:95) at a dose of 20 mg (in 3 mL)/ kg was intraperitoneally administered to rats. ** Blood from each rat (approximately 0.12 mL) was collected in a chilled Eppendorf tube at 0, 5, 15, 30, 60, 90, 120, 180, 240, 360, 480, and 600 min after irinotecan administration.

[15] EVALUATION OF THE IN VITRO/IN VIVO DRUG INTERACTION POTENTIAL OF BST204, A PURIFIED DRY EXTRACT OF GINSENG, AND ITS FOUR BIOACTIVE GINSENOSIDES THROUGH CYTOCHROME P450 INHIBITION/INDUCTION AND UDP-GLUCURONOSYLTRANSFERASE INHIBITION.
YU FEN ZHENG,SOO HYEON BAE,EU JIN CHOI,ET AL.
FOOD CHEM TOXICOL 2014 Vol.68(),117-27 $50850 [Full]

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside R-Rh2

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0-50 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Equivocal

Remark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and IC50 values of ginsenoside S-Rg3 in reversible inhibition CYP450 (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5) was > micromolar.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside R-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0-50 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Equivocal

Remark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and IC50 values of ginsenoside S-Rg3 in reversible inhibition CYP450 (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5) was > 50 microlar.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside S-Rg3

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0-50 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Equivocal

Remark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and IC50 values of ginsenoside S-Rg3 in reversible inhibition CYP450 (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5) was > 50 micromolar.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : Ginsenoside S-Rh2

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0-50 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Equivocal

Remark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and IC50 values of ginsenoside S-Rg3 in reversible inhibition CYP450 (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5) was > 50 micromolar.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : BST204 (a purified dry extract of gineseng)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0-50 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Equivocal

Remark : The inhibitory potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and IC50 values of BST 204 in reversible inhibition CYP450 (CYP1A2, CYP2A6, CYP2C19, CYP2E1, and CYP3A4/5) was > 50 micromolar.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : BST204 (a purified dry extract of ginseng)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0-50 micromolar

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : The inhibition potency of BST204 and its bioactive ginsenosides, R-Rg3, S-Rg3, R-Rh2 and S-Rh2, was determined using a nine-CYP isozyme cocktail assay in pooled human liver microsomes and BST204 slightly inhibited CYP2C8, CYP2D6, CYP2C9, and CYP2B6 activities with IC50 values of 17.4, 26.8, 31.5, and 49.7 micrograms/mL, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : BST204 (a purified dry extract of ginseng)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 0.1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 0.1 microgram/mL BST204 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.00 +/- 0.0588, 0.984 +/- 0.113 and 0.922 +/- 0.109, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : BST204 (a purified dry extract of ginseng)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 1 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 0.1 microgram/mL BST204 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.01 +/- 0.188, 0.975 +/- 0.0915 and 0.856 +/- 0.148, respectively.

Part Used : -
Activity : DRUG INTERACTION

Solvent/Active Compound : BST204 (a purified dry extract of ginseng)

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 10 microgram/mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Negative

Remark : Induction potential of 10 microgram/mL BST204 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.08 +/- 0.148, 0.940 +/- 0.198 and 0.976 +/- 0.190, respectively.

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