| Synonym |
| Thai / English name |
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 200 (M/F = 196/4)N(Treatment) : 1Sex : Both sexAge : Median age of patients was 68 years (range, 36-82 years)Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : PositiveRemark : Potential interaction : decreased anticoagulation.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 11,424N(Treatment) : -Sex : Both sexAge : >/=18 yearsRoute : Oral administrationDose/Conc.(herb) : -Duration : 2000-2001Type of interaction : PharmacokineticsInteraction with drug : Furosemide*/FrusemideDose/Conc.(drug) : -Result : PositiveRemark : Ginseng was associated with the potential for modulate hypertension due to combined use with furosemide.Note : Subjects: Of the adult National population Health Survey respondents (n=11,424), 9.3% reported the use of at least 1 natural health product in the past 2 days in 2000-2001.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times daily (standardized to 50% ginsenosides)Duration : 28 daysType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 8 mgResult : NegativeRemark :Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times daily (standardized to 5% ginsenosides)Duration : 28 daysType of interaction : PharmacokineticsInteraction with drug : CaffeineDose/Conc.(drug) : 100 mgResult : PositiveRemark :Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times daily (standardized to 5% ginsenosides)Duration : 28 daysType of interaction : PharmacokineticsInteraction with drug : ChlorzoxazoneDose/Conc.(drug) : 500 mgResult : NegativeRemark : Long term administration of P. ginseng had no modulatory effect on CYP2E1.Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12 (M/F=6/6)N(Treatment) : 12 (M/F=6/6)Sex : Both sexAge : 67+/-5.2 yrs.Route : Oral administrationDose/Conc.(herb) : 500 mg three times daily (standardized to 5% ginsenosides)Duration : 28 daysType of interaction : PharmacokineticsInteraction with drug : Debrisoquin*/Debrisoquine/Debrisochinum/IsocaramidineDose/Conc.(drug) : 5 mgResult : PositiveRemark :Note : Twelve healthy volunteers were randomly assigned to receive each botanical supplement for 28 days followed by a 30-day washout period. Probe drug cocktails of midazolam, caffeine, chlorzoxazone and debrisoquine were administered before (days -1, 0) and at the end of supplementation (days 27, 28). Pre- and post-supplementation phenotypic ratios were determined for CYP3A4, CYP1A2, CYP2E1 and CYP2D6 using 1-hydroxymidazolam/midazolam serum ratios (1-hour), paraxanthine/caffeine serum ratios (6-hour), 6-hydroxychlorzoxazone/chlorzoxazone serum ratios (2-hour) and debrisoquine urinary recovery ratios (8-hour), respectively.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : GinsenosidesType of experiment : humanType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : WarfarinDose/Conc.(drug) : -Result : NegativeRemark : P. quinquefolius reduced effects of warfarin in healthy volunteers, but P. ginseng had no effect.Note : Data incomplete, data from review article.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Case reportN(Total) : 1N(Treatment) : 1Sex : MaleAge : 26 yrs.Route : Oral administrationDose/Conc.(herb) : Daily ingestion of Panax ginseng via energy drinksDuration : 3 monthsType of interaction : PharmacodynamicsInteraction with drug : Imatinib*/Glivec/Imatinib mesylateDose/Conc.(drug) : 400 mg dailyResult : PositiveRemark :Note : A 26-year-old man with chronic myelogenous leukemia who had taken imatinib 400 mg daily for 7 years with no complications presented with right upper quadrant pain. Laboratory test results included alanine aminotransferase 1069 U/L, aspartate aminotransferase 481 U/L, alkaline phosphatase 124 IU/L, total bilirubin 1.4 mg/dL, albumin 4.0 g/dL, and international normalized ratio 1.08. Liver biopsy showed acute lobular hepatitis favoring a drug-induced etiology, and a diagnosis of imatinib-induced hepatotoxicity was made. The patient's only lifestyle modification prior to the diagnosis of hepatotoxicity was daily ingestion of Panax ginseng via energy drinks for the past 3 months. Both imatinib and ginseng were discontinued, and the patient was treated with a short course of corticosteroids. Imatinib was later restarted at the same dose with no recurrent elevations in his liver enzyme levels. They propose that the patien's late-onset imatinib-associated hepatotoxicity was due to an interaction between ginseng and imatinib through CYP3A4.
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : in vivoType of animal : mouseType of study : -N(Total) :N(Treatment) :Sex : MaleAge : -Route : Sub-cutaneousDose/Conc.(herb) : corticosterone + 800 mg/kg GWEDuration : 22 daysType of interaction : PharmacokineticsInteraction with drug : CorticosteroneDose/Conc.(drug) : 20 mg/kgResult : PositiveRemark : Serum corticosterone was significantly increased in the corticosterone-treated mice. Treatment with GWE (800 and 400 mg/kg) during corticosterone treatment reduced or partially antagonized the effects induced by corticosterone toward the normal values of the controls.Note : - Sixty male mice were divided into five matched groups (n = 12 for each group): the control group (n = 12 for each group): the control group, the corticosterone group (CORT), the corticosterone + 800 mg/kg GWE group (CORT + GWEH), the corticosterone + 400 mg/kg GWE group (CORT + GWEM) and the corticosterone + 200 mg/kg GWE group (CORT + GWEL). Control group and corticosterone groups were given distilled water. - GWE = water extract of Panax sinseng
Part Used : รากActivity : DRUG INTERACTIONSolvent/Active Compound : waterType of experiment : -Type of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Sub-cutaneousDose/Conc.(herb) : corticosterone + 400 mg/kg GWEDuration : 22 daysType of interaction : PharmacokineticsInteraction with drug : CorticosteroneDose/Conc.(drug) : 20 mg/kgResult : PositiveRemark : Serum corticosterone was significantly increased in the corticosterone-treated mice. Treatment with GWE (800 and 400 mg/kg) during corticosterone treatment reduced or partially antagonized the effects induced by corticosterone toward the normal values of the controls.Note : - Sixty male mice were divided into five matched groups (n = 12 for each group): the control group (n = 12 for each group): the control group, the corticosterone group (CORT), the corticosterone + 800 mg/kg GWE group (CORT + GWEH), the corticosterone + 400 mg/kg GWE group (CORT + GWEM) and the corticosterone + 200 mg/kg GWE group (CORT + GWEL). Control group and corticosterone groups were given distilled water. - GWE = water extract of Panax sinseng
