ARALIACEAE Panax ginseng  C.A. Mey.

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 Thai / English name

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[2-2] of 2 article(s) found

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[2] EVALUATION OF THE IN VITRO/IN VIVO DRUG INTERACTION POTENTIAL OF BST204, A PURIFIED DRY EXTRACT OF GINSENG, AND ITS FOUR BIOACTIVE GINSENOSIDES THROUGH CYTOCHROME P450 INHIBITION/INDUCTION AND UDP-GLUCURONOSYLTRANSFERASE INHIBITION.
YU FEN ZHENG,SOO HYEON BAE,EU JIN CHOI,ET AL.
FOOD CHEM TOXICOL 2014 Vol.68(),117-27  $50850 [Full]

Part Used : -
Activity : CYP2B6 INDUCTION
Solvent/Active Compound : Ginsenoside S-Rh2
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 0.1 microgram/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Negative
Remark : Induction potential of 0.1 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.02 +/- 0.014, 1.07 +/- 0.0285, and 0.961 +/- 0.0320, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION
Solvent/Active Compound : Ginsenoside S-Rh2
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 1 microgram/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Negative
Remark : Induction potential of 1 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.959 +/- 0.0106, 1.23 +/- 0.211, and 0.885 +/- 0.0419, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION
Solvent/Active Compound : Ginsenoside S-Rh2
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 10 microgram/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Negative
Remark : Induction potential of 10 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.03 +/- 0.0160, 1.08 +/- 0.400, and 0.835 +/- 0.0347, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION
Solvent/Active Compound : Ginsenoside S-Rh2
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 0.1 microgram/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Negative
Remark : Induction potential of 01 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.946 +/- 0.0442, 0.987 +/- 0.112, and 0.910 +/- 0.0513, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION
Solvent/Active Compound : Ginsenoside S-Rh2
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 1 microgram/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Negative
Remark : Induction potential of 1 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 0.961 +/- 0.0621, 1.023 +/- 0.0650, and 0.881 +/- 0.114, respectively.

Part Used : -
Activity : CYP2B6 INDUCTION
Solvent/Active Compound : Ginsenoside S-Rh2
Type of experiment : in vitro
Type of animal : -
Type of study : -
N(Total) : -
N(Treatment) : -
Sex : -
Age : -
Route : -
Dose/Conc.(herb) : 10 microgram/mL
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : -
Dose/Conc.(drug) : -
Result : Negative
Remark : Induction potential of 10 microgram/mL ginsenoside S-Rh2 on activities of CYP1A2, CYP2B6 and CYP3A4/5 in three different lots of cryopreserved human hepatocytes. Fold increase enzyme activity in each CYP were 1.04 +/- 0.0633, 1.13 +/- 0.191, and 0.860 +/- 0.0586, respectively.


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