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ARALIACEAE Panax ginseng C.A. Mey.

Synonym

none ...

Thai / English name

โสม*

[1-1] of 1 article(s) found

หน้า 1

[1] PREVENTIVE ACTION OF PANAX GINSENG ROOTS IN HYPERCORTISOLISM-INDUCED IMPAIRMENT OF HIPPOCAMPAL NEURONS IN MALE C57BL/6N MICE.
ZHONGLI WANG,JIANGUO DAI,LIN CHEN,ET AL.
PHYTOTHER RES 2011 Vol.25(),1242-5 $36280 [Full]

Part Used : ราก
Activity : DRUG INTERACTION

Solvent/Active Compound : water

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) :
N(Treatment) :

Sex : Male
Age : -

Route : Sub-cutaneous
Dose/Conc.(herb) : corticosterone + 800 mg/kg GWE

Duration : 22 days
Type of interaction : Pharmacokinetics

Interaction with drug : Corticosterone
Dose/Conc.(drug) : 20 mg/kg

Result : Positive

Remark : Serum corticosterone was significantly increased in the corticosterone-treated mice. Treatment with GWE (800 and 400 mg/kg) during corticosterone treatment reduced or partially antagonized the effects induced by corticosterone toward the normal values of the controls.

Note : - Sixty male mice were divided into five matched groups (n = 12 for each group): the control group (n = 12 for each group): the control group, the corticosterone group (CORT), the corticosterone + 800 mg/kg GWE group (CORT + GWEH), the corticosterone + 400 mg/kg GWE group (CORT + GWEM) and the corticosterone + 200 mg/kg GWE group (CORT + GWEL). Control group and corticosterone groups were given distilled water. - GWE = water extract of Panax sinseng

Part Used : ราก
Activity : DRUG INTERACTION

Solvent/Active Compound : water

Type of experiment : -
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Sub-cutaneous
Dose/Conc.(herb) : corticosterone + 400 mg/kg GWE

Duration : 22 days
Type of interaction : Pharmacokinetics

Interaction with drug : Corticosterone
Dose/Conc.(drug) : 20 mg/kg

Result : Positive

Remark : Serum corticosterone was significantly increased in the corticosterone-treated mice. Treatment with GWE (800 and 400 mg/kg) during corticosterone treatment reduced or partially antagonized the effects induced by corticosterone toward the normal values of the controls.

Note : - Sixty male mice were divided into five matched groups (n = 12 for each group): the control group (n = 12 for each group): the control group, the corticosterone group (CORT), the corticosterone + 800 mg/kg GWE group (CORT + GWEH), the corticosterone + 400 mg/kg GWE group (CORT + GWEM) and the corticosterone + 200 mg/kg GWE group (CORT + GWEL). Control group and corticosterone groups were given distilled water. - GWE = water extract of Panax sinseng

Part Used : ราก
Activity : DRUG INTERACTION

Solvent/Active Compound : water

Type of experiment : in vivo
Type of animal : mouse

Type of study : -

N(Total) :
N(Treatment) :

Sex : Female
Age : -

Route : Sub-cutaneous
Dose/Conc.(herb) : corticosterone + 200 mg/kg GWE

Duration : 22 days
Type of interaction : Pharmacokinetics

Interaction with drug : Corticosterone
Dose/Conc.(drug) : 20 mg/kg

Result : Negative

Remark : Serum corticosterone was significantly increased in the corticosterone-treated mice. Treatment with GWE (800 and 400 mg/kg) during corticosterone treatment reduced or partially antagonized the effects induced by corticosterone toward the normal values of the controls.

Note : - Sixty male mice were divided into five matched groups (n = 12 for each group): the control group (n = 12 for each group): the control group, the corticosterone group (CORT), the corticosterone + 800 mg/kg GWE group (CORT + GWEH), the corticosterone + 400 mg/kg GWE group (CORT + GWEM) and the corticosterone + 200 mg/kg GWE group (CORT + GWEL). Control group and corticosterone groups were given distilled water. - GWE = water extract of Panax sinseng

หน้า 1

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