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Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : BST204Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg/kgDuration : **Type of interaction : Non-specifiedInteraction with drug : Irinotecan*/Camptothecin-11/CPT-11Dose/Conc.(drug) : -Result : NegativeRemark : - BST204 and irinotecan co-administration. Thirty mimutes prior to irinotecan administration, BST204 (suspended in distilled water) at a dose of 400 mg (in 10mL)/kg was orally administered. Then, Irinotecan (dissolved in DMSO: 0.9% NaCl injectable solution, v/v = 5:95) at a dose of 20 mg (in 3 mL)/ kg was intraperitoneally administered to rats. ** Blood from each rat (approximately 0.12 mL) was collected in a chilled Eppendorf tube at 0, 5, 15, 30, 60, 90, 120, 180, 240, 360, 480, and 600 min after irinotecan administration.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : BST204 (a purified dry extract of ginseng)Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 400 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : Irinotecan*/Camptothecin-11/CPT-11Dose/Conc.(drug) : -Result : NegativeRemark : Irinotecan 20 mg/kg (intraperitoneal administration).
