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Part Used : ราก

Activity : DRUG INTERACTION

Solvent/Active Compound : ginsenosides*

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : 24 h of incubation at 37 degress celsius

Type of interaction : Pharmacokinetics

Interaction with drug : Cefotaxime

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: The combination of cefotaxime with ginsenosides significantly improved antibacterial activity (MIC=2.5-50 micrograms/mL for MRSA1, 5-50 micrograms/mL for MRSA2, and 5-50 icrograms/mL for MRSA3), FIC indexes had shown the combination of ginsenosides and cefotaxime had an additive effect againt MRSA.

Note : *Compound: Ginsenosides contained Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Rh2. The combination effect of commercial antibiotics and ginsenosides was determined by a checkboard assay and the effects were evaluated using fractional inhibitory concentration (FIC) indexs. MRSA= methicillin-resistant Staphylococcus aureus strains.

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