Part Used : ราก
Activity : ANTIBACTERIAL ACTIVITY
Solvent/Active Compound : ginsenosides*
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : 24 h of incubation at 37 degress celsius
Type of interaction : Pharmacokinetics
Interaction with drug : Cefotaxime
Dose/Conc.(drug) : -
Remark : Result: The combination of cefotaxime with ginsenosides significantly improved antibacterial activity (MIC=2.5-50 micrograms/mL for MRSA1, 5-50 micrograms/mL for MRSA2, and 5-50 micrograms/mL for MRSA3), FIC indexes had shown the combination of ginsenosides and cefotaxime had an additive effect againt MRSA.
Note : *Compound: Ginsenosides contained Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Rh2. The combination effect of commercial antibiotics and ginsenosides was determined by a checkboard assay and the effects were evaluated using fractional inhibitory concentration (FIC) indexs. MRSA= methicillin-resistant Staphylococcus aureus strains.