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Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Panax ginseng (PG) suspensionType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : gastric gavage feeding of PG suspension 150 mg/kg/dayDuration : 14 consecutive daysType of interaction : PharmacokineticsInteraction with drug : FexofenadineDose/Conc.(drug) : -Result : PositiveRemark : A single dose of fexofenadine (100 mg/kg for oral dose) was administered after 14 days of feeding PGS. Blood samples were collected from 0 to 12 h. and levels of fexofenadine were measured by LC-MS/MS. Result: PG deoreased the AUC between 0-12h, decreased Cmax, and decreased ratios of brain to plasma concentration. The mean bioavailability of fexofenadine was decreased by 16.1%.Note : Long term administration of Panax ginseng to rats might induce both intestinal and brain endothelium p-glycoprotein expression. In addition, long term use of Panax ginseng reduced the bioavailability of concurrently administered fexofenadine.
Part Used : รากActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : Panax ginseng (PG) suspensionType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : gastric gavage feeding of PG suspension 150 mg/kg/dayDuration : 14 consecutive daysType of interaction : PharmacokineticsInteraction with drug : FexofenadineDose/Conc.(drug) : -Result : PositiveRemark : A single dose of fexofenadine (10 mg/kg for intravenous) was administered after 14 days of feeding PGS. Blood samples were collected from 0 to 2 h. and levels of fexfenadine were measured by LC-MS/MS. Result: PG reduced ratios of brain to plasma concentration.Note : Long term administration of Panax ginseng to rats might induce both intestinal and brain endothelium p-glycoprotein expression. In addition, long term use of Panax ginseng reduced the bioavailability of concurrently administered fexofenadine.