Part Used : ไม่ระบุ
Activity : CYTOTOXIC ACTIVITY
Solvent/Active Compound : 20(S)-ginsenoside Rg3 (Rg3)
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 100 micromolar
Duration : lncubation for 30 min
Type of interaction : Pharmacodynamics
Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : 2.5 micromolar
Remark : Rg3 is able to sensitize hepatocellular carcinoma cell (HCC) to doxorbicin induced cell death in large part through the suppression of autophagy. This sensitization was observed in all the HCC tested, but not in normal human liver cell line, suggesting that Rg3 synergism with doxorubicin is selective to cancer cells. The minimal amount of caspase-3 cleavage was seen in some of the drying cells treated with Rg3 and doxorubicin when compared to the TRAlL induced caspase-3 cleavage. Thus, Rg3 and doxorubicin-induced cell death seems to be a largely a caspase-independent process.
